Results 31 to 40 of about 590 (96)

Lysophosphatidic Acid Synergizes With 1,25‐Dihydroxyvitamin D to Promote Fibroblast Growth Factor‐23 Synthesis via MAPK Signaling and Induction of the IL12A Gene

open access: yesThe FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Birol Ay   +7 more
wiley   +1 more source

Individual‐Level Effects of a Digital Behavioural Treatment for Chronic Pain: Proof‐of‐Concept of a Single‐Case Experimental Design Study

open access: yesEuropean Journal of Pain, Volume 29, Issue 10, November 2025.
ABSTRACT Background Chronic pain affects 20%–30% of the population worldwide, leading to significant distress, disability and financial burden. Pain management strategies focusing on pain reduction have shown limited effects on functioning; however, behavioural treatments aimed at enhancing resilience have demonstrated strong empirical support. Digital
Haya Al Sharaa   +11 more
wiley   +1 more source

Relating characteristics of global biodiversity targets to reported progress

open access: yesConservation Biology, Volume 33, Issue 6, Page 1360-1369, December 2019., 2019
Abstract To inform governmental discussions on the nature of a revised Strategic Plan for Biodiversity of the Convention on Biological Diversity (CBD), we reviewed the relevant literature and assessed the framing of the 20 Aichi Biodiversity Targets in the current strategic plan.
Elizabeth J. Green   +6 more
wiley   +1 more source

CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation

open access: yesEuropean Journal of Immunology, Volume 55, Issue 9, September 2025.
The innate actions of the immune system allow for a rapid response to potential threats. Here we show that upon classical T cell activation, both murine and human adaptive immune cells can acquire innate capabilities allowing them to respond to cytokines in a TCR independent manner.
Nima Yassini   +4 more
wiley   +1 more source

The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells

open access: yesJournal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
T follicular helper cells (TFH) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFH cells are clear.
Xueyang Zou   +5 more
wiley   +1 more source

स्मार्तज्ञानपरंपरायां संस्काराणां प्रासङ्गिकता (The Relevance of Rituals in the Smārta Tradition)

open access: yesPrachi Prajna, 2023
It is true that the dignity of India is unique and admirable among many nations in the world. Because the Vedas are the foundation point of the land of India.
Mami Mahanta
doaj  

Investigating Polyreactivity of CD4+ T Cells to the Intestinal Microbiota

open access: yesEuropean Journal of Immunology, Volume 55, Issue 4, April 2025.
T‐cell recognition of microbiota‐derived epitopes is key to immune homeostasis. Here, we used an unbiased screening platform to identify novel immunogenic epitopes from Akkermansia muciniphila and Bacteroides thetaiotaomicron. We demonstrated that these epitopes are conserved across multiple other bacterial strains, suggesting their potential relevance
Ahmed Saadawi   +5 more
wiley   +1 more source

Using hope theory to understand changes from professional learning in inclusive education

open access: yesBritish Educational Research Journal, Volume 51, Issue 1, Page 299-320, February 2025.
Abstract Professional learning for quality teaching is a lifelong enterprise. Nevertheless, it entails a considerable cost with varying outcomes. Drawing on Snyder's hope theory and Pantic's teacher agency, this paper aims to present a model aimed at deepening our understanding of teachers' intentions and competencies in inclusive education.
Eunjae Park   +3 more
wiley   +1 more source

Smart city initiatives: Street lights

open access: yesSmart Cities and Regional Development Journal, 2018
In the near future, smart city technologies could play a fundamental role in urban sustainable development; economically, socially, and environmentally.
John M. POLIMENI   +1 more
doaj   +1 more source

Probing TCR Specificity Using Artificial In Vivo Diversification of CDR3 Regions

open access: yesEuropean Journal of Immunology, Volume 55, Issue 1, January 2025.
Diversification of transgenic TCRs by CRISPR/Cas9‐mediated mutagenesis of Tcra and Tcrb chain genes in vivo converts monoclonal repertoires of known specificity into an oligoclonal pool of TCRs of altered antigen reactivities. This generally applicable approach helps to identify crucial amino acid residues in the CDR3 regions required for antigen ...
Orlando B. Giorgetti   +2 more
wiley   +1 more source

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