Results 61 to 70 of about 3,067,929 (312)

Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role

Cell Death and Disease, 2022
PTENα and PTENβ (PTENα/β), two long translational variants of phosphatase and tensin homolog on chromosome 10 (PTEN), exert distinct roles from canonical PTEN, including promoting carcinogenesis and accelerating immune-resistant cancer progression ...
Cheng Zhang, Hong-Ming Ma, Shuang-Shu Dong, Na Zhang, Ping He, Meng-Kai Ge, Li Xia, Jian-Xiu Yu, Qiang Xia, Guo-Qiang Chen, Shao-Ming Shen   +10 more
doaj   +1 more source

Direct evidence of soft mode behavior near the Burns' temperature in PbMg$_{1 / 3}$Nb$_{2 / 3}$O$_{3}$ (PMN) relaxor ferroectric

, 2002
Inelastic neutron scattering measurements of the relaxor ferroelectric PbMg$_{1 / 3}$Nb$_{2 / 3}$O$_{3}$ (PMN) in the temperature range 490~K$
A. Naberezhnov, D. Viehland, E. Husson, E.V. Colla, F. Schwabl, G. Burns, G. Burns, I.F. Chang, I.G. Siny, I.G. Siny, I.G. Siny, I.G. Siny, I.G. Siny, L.E. Cross, M. de Mathan, P.M. Gehring, P.N. Timonin, R. Currat, R.B. Griffiths, R.K. Wehner, S. B. Vakhrushev, S. M. Shapiro, S. Vakrushev, S.B. Vakhrushev, S.B. Vakhrushev, S.B. Vakhrushev, V. Bovtun, V.A. Stephanovich, V.I. Torgahsev, V.L. Aksenov, V.L. Aksenov, W.A. Kamitakahara   +31 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Vacuum stability, neutrinos, and dark matter

, 2012
Motivated by the discovery hint of the Standard Model (SM) Higgs mass around 125 GeV at the LHC, we study the vacuum stability and perturbativity bounds on Higgs scalar of the SM extensions including neutrinos and dark matter (DM). Guided by the SM gauge
A Djouadi, B Kayser, B Schrempp, C Burgess, Chian-Shu Chen, E Aprile, E Witten, G Aad, G Altarelli, G Gelmini, G Isidori, H Arason, I Gogoladze, I Gogoladze, J Casas, J Casas, J Chakrabortty, J Elias-Miro, J Espinosa, J McDonald, J Schechter, K Nakamura, M Cirelli, M Cirelli, M Gonderinger, M Holthausen, M Lindner, M Lindner, M Sher, ME Machacek, ME Machacek, ME Machacek, N Cabibbo, PB Arnold, R Foot, R Mohapatra, RN Lerner, RN Mohapatra, S Weinberg, T Cheng, T Cheng, T Clark, T Hambye, V Silveira, W Konetschny, X-G He, Y Cai, Yong Tang   +47 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Determination of 4-tert-butyl pyrocatechol content in styrene with high accuracy using a chromatographic device under safe conditions: a laboratory study

Scientific Reports
A novel analytical method was developed for the determination of 4-tert-butylpyrocatechol (TBC) in styrene. Various measurement methods were compared. TBCs were analyzed using a straightforward method, which had significantly less contamination, and no ...
Mohammad Heydari, Mohammad Reza Ghavidel
doaj   +1 more source

Targeted Micellar Phthalocyanine for Lymph Node Metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model

Nano-Micro Letters, 2021
Highlights Small-sized trastuzumab-targeted micelles (T-MP) were engineered using a surfactant-stripping approach that yielded concentrated phthalocyanines with strong near infrared absorption.
Hai-Yi Feng, Yihang Yuan, Yunpeng Zhang, Hai-Jun Liu, Xiao Dong, Si-Cong Yang, Xue-Liang Liu, Xing Lai, Mao-Hua Zhu, Jue Wang, Qin Lu, Quanjun Lin, Hong-Zhuan Chen, Jonathan F. Lovell, Peng Sun, Chao Fang   +15 more
doaj   +1 more source

Grand Unified Yukawa Matrix Ansatz: The Standard Model Fermion Mass, Quark Mixing and CP Violation Parameters

, 2010
We propose a new mass matrix ansatz: At the grand unified (GU) scale, the standard model (SM) Yukawa coupling matrix elements are integer powers of the square root of the GU gauge coupling constant \varepsilon \equiv \sqrt{\alpha_{\text{GU}}}, multiplied
Cecotti S, Heckman J J, Heckman J J, Nelson A E, Weinberg S, Zhang De-Hai, Zhang Yong-Chao   +6 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source