Results 81 to 90 of about 3,067,929 (312)

USE OF NEW EUROPEAN FURAZIDINIUM IN THERAPY OF ACUTE INFECTIONS OF THE URINARY TRACTS IN WOMEN

Медицинский совет, 2017
Uncomplicated infection of lower urinary tract is one of most common reason to visit a doctor among women. Statistically there are about 36 million cases of acute cystitis registered yearly in Russia. The treatment of acute cystitis is usually empirical,
A. O. Danilov
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Aspects of Domain-Wall Standard Model

, 2018
We have recently proposed a setup of the "Domain-Wall Standard Model" in a non-compact 5-dimensional space-time, where all the Standard Model (SM) fields are localized in certain domains of the 5th dimension.
Okada, Nobuchika, Raut, Digesh, Villalba, Desmond   +2 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A Predictive Mirror Twin Higgs with Small $\mathbf{Z}_2$ Breaking

, 2019
The twin Higgs mechanism is a solution to the little hierarchy problem in which the top partner is neutral under the Standard Model (SM) gauge group. The simplest mirror twin Higgs (MTH) model -- where a $\mathbf{Z}_2$ symmetry copies each SM particle --
Harigaya, Keisuke, McGehee, Robert, Murayama, Hitoshi, Schutz, Katelin   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Role of prior HPV infection and CD4 T-cell count in modulating cellular immune responses to a three-dose nonavalent HPV vaccine schedule in PWH receiving ART

BMC Medicine
Background Most studies on HPV vaccination have focused on the antibody response and on bivalent and quadrivalent vaccines. For these reasons, an evaluation of T-cell responses in PWH on effective ART to the Gardasil 9® vaccine according to prior HPV ...
Eeva Tortellini, Mariasilvia Guardiani, Anna Carraro, Lorenzo Ansaldo, Sara Corazza, Sara Giovanna De Maria, Silvia Garattini, Mirko Barresi, Valeria Belvisi, Maria Antonella Zingaropoli, Federica Dominelli, Carmen Falvino, Fabio Mengoni, Alessandro Tavelli, Cristina Giambi, Claudio Maria Mastroianni, Cosmo Del Borgo, Raffaella Marocco, Miriam Lichtner   +18 more
doaj   +1 more source

Binary Estimator Selection Methods for Hearing Aids With a Remote Microphone

IEEE Access
Using a high signal-to-noise ratio remote microphone (RM) with hearing aids (HAs) is advantageous for HA users. However, the benefit depends significantly on the properties of the wireless channel.
Vasudha Sathyapriyan, Michael S. Pedersen, Mike Brookes, Jan Ostergaard, Patrick A. Naylor, Jesper Jensen   +5 more
doaj   +1 more source

SMS in PACE 2020

CoRR, 2020
3 pages, 3 appendix pages, 0 figures. Submitted as a solver description of a solver in Parameterized Algorithms and Computational Experiments Challenge ...
openaire   +2 more sources