Results 21 to 30 of about 1,350,741 (373)
Cogent Medicine, 2020 Spinal muscular atrophy (SMA) includes genetic heterogeneous diseases characterized by muscle weakness and atrophy. There are at least two risk factors for SMA patients to develop urinary dysfunctions: 1) the neural degeneration, that influences the ...
Francesca Destro +4 more
doaj +1 more source
Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy [PDF]
, 2013 BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease resulting from mutations in the survival motor neuron 1 (SMN1) gene. Recent breakthroughs in preclinical research have highlighted several potential novel therapies for SMA, increasing ...
Gillingwater, T. H. +4 more
core +3 more sources
Journal of Medicinal Chemistry, 2018 SMA is an inherited disease that leads to loss of motor function and ambulation and a reduced life expectancy. We have been working to develop orally administrated, systemically distributed small molecules to increase levels of functional SMN protein ...
H. Ratni +27 more
semanticscholar +1 more source
Operational Risk framework and Standardised Measurement Approach (SMA) [PDF]
Risk Management Magazine, 2023 On December 2017, the Basel Committee published the “Basel III: Finalising post-crisis reforms” (also known as Basel IV) that introduces the Standardised Measurement Approach (SMA) to define the Pillar I operational risk capital requirement that is ...
Paolo Fabris +2 more
doaj +1 more source
ANALISIS SMA NEGERI BERPRESTASI DIBIDANG EKSTRAKURIKULER FUTSAL KOTA BENGKULU
Kinestetik, 2017 Penelitian ini bertujuan untuk mengetahui prestasi ekstrakurikuler futsal. Metode yang digunakan adalah metode penelitian deskriptif. Subjek penelitian adalah 9 Sekolah Menengah Atas Negeri di Kota Bengkulu. Instrumen dari penelitian ini yaitu Observasi,
Faisal Mandala Siregar +2 more
doaj +1 more source
Kinetostatics of a Robotic Prehension Device Driven by Shape Memory Alloy Elements [PDF]
Robotica & Management, 2023 This paper presents the kinetostatic calculus for a robotic prehension device driven by shape memory alloy elements. The constructive-functional scheme is presented, as well as the forces that occur in the prehension process.
Daniel-Gheorghe Vela +2 more
doaj +1 more source
Gastric perforation and pancreatitis manifesting after an inadvertent nissen fundoplication in a patient with superior mesenteric artery syndrome. [PDF]
, 2009 Superior mesenteric artery (SMA) syndrome is an uncommon but well-recognized clinical entity. It can lead to proximal small bowel obstruction and severe morbidity and mortality in lieu of late diagnosis and concomitant existing comorbidities. We report a
Estrada, JJ +5 more
core +3 more sources
PROFIL KEMAMPUAN INTERPRETASI GRAFIK KINEMATIKA SISWA SMA KELAS X
Gravity: Jurnal Ilmiah Penelitian dan Pembelajaran Fisika, 2017 Graphic interpretation is an important part of studying science. Graph interpretation is part of a representation that shows students' conceptual understanding.
Yustiandi Yustiandi, Duden Saepuzaman
doaj +1 more source
Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy [PDF]
, 2016 Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity.
Brophy, Peter J. +9 more
core +3 more sources
Journal of Neuromuscular Diseases, 2019 Objective: Spinal muscular atrophy (SMA) is a progressive autosomal recessive motor neuron disease caused by loss of the SMN1 gene. Based on randomized clinical trials in children with SMA type 1 and 2, Nusinersen has been approved as the first treatment
M. Walter +10 more
semanticscholar +1 more source