Results 41 to 50 of about 357,035 (311)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Submillimeter Array (SMA) Newsletter January 2019

, 2019
Submillimeter Array (SMA) Newsletter January 2019 Blundell, Raymond Submillimeter Array Newsletter | Number 27 | January 2019 CONTENTS 1 From the Director SCIENCE HIGHLIGHTS: 2 SMA Observations of AT2018cow: A Prototype For ...
Blundell, Raymond
core   +1 more source

SMA-TB Clinical trial research team's thoughts and opinions

, 2022
In this video SMA-TB Clinical trial research team members from Georgia and South Africa share their thoughts and opinions regarding the SMA-TB project and its impact both at scientific and personal level.
Vashakidze, Sergo, Bolotashvili, Maia, Pillay, Natasha, Shurgaia, Marika, Kiria, Nana, Seiphetlo, Thabiso, Avaliani, Zaza, Bajelidze, Ketevan, Bedukadze, Tamar, Barbakadze, Ketevan, Gogichadze, Nino, Kupreishvili, Lali, Aspindzelashvili, Rusudan, Korinteli, Tamar, Tukvadze, Nestani   +14 more
core   +1 more source

SMA—The Smyle Modeling Approach [PDF]

, 2011
This paper introduces the model-based software development lifecycle model SMA--the Smyle Modeling Approach--which is centered around Smyle. Smyle is a dedicated learning procedure to support engineers to interactively obtain design models from requirements, characterized as either being desired (positive) or unwanted (negative) system behavior. Within
Benedikt Bollig, Joost-Pieter Katoen, Carsten Kern, Martin Leucker   +3 more
openaire   +3 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Submillimeter Array (SMA) Newsletter March 2012

, 2012
Submillimeter Array (SMA) Newsletter March 2012 Blundell, Raymond Submillimeter Array Newsletter | Number 13 | March 2012 CONTENTS 1 From the Director SCIENCE HIGHLIGHTS: 2 Dissecting a Bright Cluster-Lensed Submillimeter Galaxy at ...
Blundell, Raymond
core   +1 more source

Preparation and characterization of a coacervate extended-release microparticulate delivery system for Lactobacillus rhamnosus

International Journal of Nanomedicine, 2011
Sk Md Athar Alli Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, IndiaBackground: The purpose of this study was to develop a mucoadhesive coacervate microparticulate system to deliver viable Lactobacillus rhamnosus ...
Alli SMA
doaj  

Enhancing the seismic performance of platforms in intermediate water depth using shape ‎memory alloy dampers [PDF]

Journal of Hydraulic Structures
Wharves supported by vertical piles are very common marine structures with suitable seismic responses. Nevertheless, they severely suffer from extensive lateral displacement in both design and service earthquake level state.
Mohammad Jafari, Hamid Bayesteh, Reza Rasti Ardakani‎   +2 more
doaj   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Submillimeter Array (SMA) Newsletter July 2013

, 2013
Submillimeter Array (SMA) Newsletter July 2013 Blundell, Raymond Submillimeter Array Newsletter | Number 16 | July 2013 CONTENTS 1 From the Director SCIENCE HIGHLIGHTS: 2 Submillimeter Galaxy Merger Leading to Massive Elliptical ...
Blundell, Raymond
core   +1 more source