Results 51 to 60 of about 451,137 (253)
Biosfer, 2023 Selection of learning media can affect the learning process that takes place in class. In addition, teachers are required to have the ability to use instructional media.
Safira Permata Dewi +2 more
doaj +1 more source
Submillimeter Array (SMA) Newsletter January 2019
, 2019 Submillimeter Array (SMA) Newsletter January 2019 Blundell, Raymond Submillimeter Array Newsletter | Number 27 | January 2019 CONTENTS 1 From the Director SCIENCE HIGHLIGHTS: 2 SMA Observations of AT2018cow: A Prototype For ...
Blundell, Raymond
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Atmosphere, 2019 This study identified the key chemical components based on an analysis of the seasonal variations of ground level PM2.5 concentrations and its major chemical constituents (sulfate, nitrate, ammonium, organic carbon, and elemental carbon) in the Seoul ...
Changhan Bae +4 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Pre-mRNA splicing-associated diseases and therapies
RNA Biology, 2023 Precursor mRNA (pre-mRNA) splicing is an essential step in human gene expression and is carried out by a large macromolecular machine called the spliceosome.
Sierra L. Love +3 more
doaj +1 more source
INNOVATIVE USE OF SHAPE MEMORY ALLOYS AS REINFORCEMENTS FOR CONCRETE BEAM-COLUMN JOINTS: AN OVERVIEW
Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ, 2023 Shape memory alloys have two unique properties of shape memory effect (SME) and superelasticity (SE) that are the ability for large inelastic deformations recovery after heating (SME) and stress removal (SE).
Mahdieh Sabbaghian, Mohammadzaman Kabir
doaj +1 more source
Submillimeter Array (SMA) Newsletter July 2019
, 2019 Submillimeter Array (SMA) Newsletter July 2019 Blundell, Raymond Submillimeter Array Newsletter | Number 28 | July 2019 CONTENTS 1 From the Director SCIENCE HIGHLIGHTS: 2 The SMA’s Key Role in Capturing the Event Horizon TelescopeM87 ...
Blundell, Raymond
core +1 more source
Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling
FEBS Open Bio, EarlyView.Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt +2 more
wiley +1 more source