Results 181 to 190 of about 55,562 (295)

Paraxanthine and azilsartan attenuate gentamicin-induced renal fibrosis via modulation of TGF-β1/Smad3/7 signaling and miRNA-21/miRNA-200b expression. [PDF]

J Transl Med
Rizk El-Adwy NS, El-Ashmawy NE, Al-Ashmawy GM, Khedr NF.   +3 more
europepmc   +1 more source

Effects of Naringenin on Diabetic Nephropathy: A Systematic Review and Meta‐Analysis of Rodent Studies

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Naringenin produces comprehensive renoprotective effects in rodent models of diabetic nephropathy. It mainly lowers blood sugar and alleviates renal dysfunction by reducing proteinuria, serum creatinine, and blood urea nitrogen. Meanwhile, naringenin improves antioxidant status by elevating glutathione and reducing malondialdehyde, and suppresses ...
Yuzhu Qu, Jie Chen, Ling Yue, Xinyue Zhang, Kongmei Ou, Yiting Wang, Runjia He, Benxiang He   +7 more
wiley   +1 more source

Antibody-conjugated SIS3-loaded PLGA@polydopamine nanoparticles alleviate cardiac fibrosis by modulating Smad3 signaling in myofibroblasts. [PDF]

J Nanobiotechnology
Chen C, Lu W, Pan Q, Cui C, Zhang Y, Wang H, Han J, Yuan S, Lin Z, Xie Y, Dou K, Hou J.   +11 more
europepmc   +1 more source

Sex‐Specific Anti‐Inflammatory Effects of Alternate Day Fasting via TLR4 and Leptin Signaling in Middle‐Aged Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ADF downregulates TLR4, reducing hypothalamic and hepatic inflammation, with stronger effects in females. ADF enhances leptin sensitivity in aging by reducing SOCS3 and upregulating ObRb, thereby improving metabolic function. ADF reduces retroperitoneal fat and glucose levels, with females experiencing greater fat loss.
Ozgen Kilic‐Erkek, Gulsah Gundogdu, Abdullah Coguplugil, Yavuz Dodurga   +3 more
wiley   +1 more source

Smad3 Cranks Up the Appetite of Infarct Macrophages [PDF]

Circulation Research, 2019
Maarten, Hulsmans, Matthias, Nahrendorf
openaire   +2 more sources

BMAL1 regulates tubular epithelial-derived exosomal miR-27a-3p to inhibit macrophage-myofibroblast transition and alleviate ischemia/reperfusion-induced renal fibrosis. [PDF]

Theranostics
Chen W, Zhao S, Yang S, Yu W, Rao T, Zhou X, Ruan Y, Zou F, Cheng F, Li W.   +9 more
europepmc   +1 more source

4‐FPAC‐Modulated Tumor‐Associated Macrophage Conditioned Media Suppresses Malignant Phenotypes and Promotes Cell‐Cycle Arrest and Apoptosis in NSCLC

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
4‐FPAC‐modulated TAM conditioned media attenuated proliferation, EMT, angiogenesis, and stemness while inducing cell‐cycle arrest and apoptosis in NSCLC cells. These anti‐tumor effects were associated with disruption of the IL8–CD163 axis, supporting the potential of 4‐FPAC as a tumor microenvironment‐targeted therapeutic agent. ABSTRACT Non‐small cell
Anjali Singh, Dhanush Danes, Suresh Balakrishnan   +2 more
wiley   +1 more source

Palmitoylation Induced Activation of SMAD3 Exacerbates Colitis by Promoting Tissue-resident Memory T Cells Differentiation. [PDF]

Inflammation
Xu Y, Ji S, Jiang P, Zhao Z, Zhou Q, Su D, Ullah S, Zhao Y, Zou X, Zhang M, Sun J, Xu G, Tang J.   +12 more
europepmc   +1 more source

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho, Marielle Saclier   +1 more
wiley   +1 more source

VHL-recruiting PROTAC attenuates AKI-CKD transition via simultaneous degradation of Smad3 and stabilization of HIF-2α. [PDF]

Cell Death Dis
Ruan Y, Wang D, Xu Y, Yang J, Chen Y, Fan J, Tang SCW, Chen W, Wang X.   +8 more
europepmc   +1 more source