Results 201 to 210 of about 55,562 (295)

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

Fluvoxamine and lycopene alleviate cisplatin-induced kidney fibrosis by modulating miR-21 and fibrotic signaling pathways. [PDF]

Sci Rep
Abu-Risha SE, Sokar SS, Mousa MA, El-Shitany NA, Elsisi AE.   +4 more
europepmc   +1 more source

Vaccination Drives Alveolar Macrophages Pool Remodeling via Training Resident Cells and Recruiting Monocyte‐Derived Cells to Defend Against Multidrug‐Resistant Acinetobacter baumannii

MedComm, Volume 7, Issue 8, August 2026.
Under homeostatic conditions, the lungs primarily harbor tissue‐resident alveolar macrophages (TR‐AMs). Intranasal immunization with A. baumannii IWC remodels the alveolar macrophage pool via two complementary mechanisms: recruitment and progressive differentiation of CD11B+CD13+ monocyte‐derived AMs, together with direct functional and epigenetic ...
Xiaomin Zhang, Yangyang Zhou, Chuanying Xiang, Ning Wang, Yan Li, Kai Chen, Yu Xie, Hong Yang, Xiangcheng Sun, Yun Shi   +9 more
wiley   +1 more source

BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/SMAD3 in TGF-β1 pathway. [PDF]

Biochem Biophys Rep
Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wang Y.   +5 more
europepmc   +1 more source

Targeting fibrosis in the treatment of lower urinary tract dysfunction

The Journal of Pathology, Volume 269, Issue 4-5, Page 493-503, August 2026.
Abstract Benign prostatic hyperplasia (BPH) is a widely prevalent age‐associated disease that is the main contributor to lower urinary tract dysfunction (LUTD) in aging men. Although prostate fibrosis has been recognized as a contributor to BPH pathophysiology, there are not any clinically available therapeutics that target this aspect of disease ...
Ajinkya R Limkar, Sophia M Vrba, Emily A Ricke, Zsuzsanna Fabry, Matthew S Lee, Kevin T McVary, William A Ricke   +6 more
wiley   +1 more source

Alhagi honey polysaccharide ameliorates carbon tetrachloride-induced liver fibrosis via modulating the gut microbiota-liver metabolism axis. [PDF]

Front Nutr
Song J, Zhao X, Cao L, Chen Y, Zhou X, Li J, You P, Zhou J, Lv Z, Ma X, Chang J.   +10 more
europepmc   +1 more source

Conjunctival Sac‐Derived Lactobacillus mucosae MM‐1 Metabolite Indole‐3‐Lactic Acid Attenuates Lens‐Induced Myopia in Mice via AHR Activation and TGF‐β/Smad Inhibition

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
This study proposes a ‘conjunctival sac microecology‐metabolite‐scleral remodelling’ regulatory axis, highlighting the potential role of conjunctival sac microbiota in maintaining ocular surface health and regulating lens‐induced myopia in mice, providing an important theoretical foundation for the development of microbiome‐based interventions for ...
Yanqing Li, Qiuyu Wu, Xilong Zhang, Luchuan Liu, Leiping Ding, Jingjing Xu, Chiwen Cheng, Yangyang Peng, Kang Yu, Wen Yao, Yijie Pi, Jiale Li, Di Wu, Jing Wei, Yifeng Yu, Tingtao Chen   +15 more
wiley   +1 more source

Super-Enhancer-Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression. [PDF]

Adv Sci (Weinh)
Lou E, Lai P, Peng G, Lu B, Jiang L, Li X, Chen J, Mo L, Mao Q, Zhang H, Fang J, Meng Y, Liu A, Gao Y, Huang A, Lin W, Hu S, Guan Z, Ye X, Liu Z, Jiang L, Zheng Y, Shi X.   +22 more
europepmc   +1 more source

Down‐Regulation of TFEB With Defective Autophagy in the Susceptibility of Aging Kidneys to Septic Acute Kidney Injury

Aging Cell, Volume 25, Issue 8, August 2026.
Aging is associated with impaired TFEB‐dependent autophagy in renal proximal tubular epithelial cells, leading to increased susceptibility to LPS‐induced injury and inflammation. Restoration of autophagy through TFEB activation or Tat–Beclin 1 treatment partially rescues autophagic function and confers protection against elderly sepsis‐associated acute
Yu Xiang, Ying Fu, Zhiwen Liu, Yu Han, Wenwen Wu, Juan Cai, Dongshan Zhang, Zheng Dong   +7 more
wiley   +1 more source

Type 2 immune profile and impaired SMAD3-mediated repair in refractory stasis dermatitis responsive to IL-4Rα blockade. [PDF]

JAAD Int
Shen C, Liu T, Li L, Yu G, Chung WH, Tao J.   +5 more
europepmc   +1 more source