Results 251 to 260 of about 55,562 (295)

Pregnancy in Women With SMAD3 Mutation

Journal of the American College of Cardiology, 2017
Women with genetic aortic disease, such as Marfan syndrome, are at increased risk of pregnancy complications, in particular those with aortic dissection [(1)][1]. Aneurysms-osteoarthritis syndrome (AOS) is an autosomal-dominant syndrome caused by SMAD3 mutations, and is characterized by ...
van Hagen, Iris, Linde, Denise, De Graaf - van de Laar, Ingrid, Mosquera, LM, Backer, J, Roos - Hesselink, Jolien   +5 more
openaire   +3 more sources

Smad3 linker phosphorylation attenuates Smad3 transcriptional activity and TGF-β1/Smad3-induced epithelial–mesenchymal transition in renal epithelial cells

Biochemical and Biophysical Research Communications, 2012
Transforming growth factor-β1 (TGF-β1) has a distinct role in renal fibrosis associated with epithelial-mesenchymal transition (EMT) of the renal tubules and synthesis of extracellular matrix. Smad3 plays an essential role in fibrosis initiated by EMT.
Suntaek Hong, Seong-Jin Kim
exaly   +3 more sources

Expression of Transforming Growth Factor β1, Smad3, and Phospho-Smad3 in Somatotropinomas and Their Relationship to Tumor Behavior

World Neurosurgery, 2021
To investigate the role of transforming growth factor β1 (TGF-β1), Smad3, and phospho-Smad3 (p-Smad3) in the invasion of somatotropinomas.In total, 45 somatotropinomas were obtained from patients who underwent surgery for the first time between 2011 and 2015 at Beijing Tiantan Hospital.
Zhenye, Li, Jianhua, Li, Xiaosong, Shan, Songbai, Gui, Chuzhong, Li, Yazhuo, Zhang   +5 more
openaire   +2 more sources

TSAd interacts with Smad2 and Smad3

Biochemical and Biophysical Research Communications, 2006
Smad-dependent signalling initiated by TGFbeta superfamily members can be modulated by a variety of interacting proteins. Using yeast two-hybrid, co-immunoprecipitation, and GST pull-down assays we identified T-cell SH2 adapter (TSAd) as a protein that interacts with Smad2 and Smad3.
K C, Richard, G E, Bertolesi, L D, Dunfield, C R, McMaster, M W, Nachtigal   +4 more
openaire   +2 more sources

Knocking out USP7 attenuates cardiac fibrosis and endothelial-to-mesenchymal transition by destabilizing SMAD3 in mice with heart failure with preserved ejection fraction

Theranostics
Background: Heart failure with preserved ejection fraction (HFpEF) is a predominant type of heart failure. Exploring new pathogenesis and identifying potential novel therapeutic targets for HFpEF is of paramount importance. Methods: HFpEF mouse model was
S. Yuan, Zimu Wang, S. Yao, Yanyan Wang, Zhonglei Xie, Jingfeng Wang, Xueting Yu, Yu Song, X. Cui, Jingmin Zhou, Junbo Ge   +10 more
semanticscholar   +1 more source

C-reactive protein promotes diabetic kidney disease via Smad3-mediated NLRP3 inflammasome activation

Molecular Therapy
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney diseases resulting in enormous socio-economic burden. Accumulated evidence has indicated that C-reactive protein (CRP) exacerbates DKD by enhancing renal inflammation and fibrosis ...
Yifan Wang, Y. You, Jian-bo Guo, Jianan Wang, Baoyi Shao, Haidi Li, Xiaoming Meng, Hui Y. Lan, Hai-yong Chen   +8 more
semanticscholar   +1 more source

The prognostic significance of Smad3, Smad4, Smad3 phosphoisoform expression in esophageal squamous cell carcinoma

Medical Oncology, 2014
Smad3 functions as an integrator of diverse signaling, including transforming growth factor β signaling and the function of Smad3 is complexly regulated by differential phosphorylation at various sites of Smad3. Despite the importance of Smad3 and its various phosphoisoforms, their prognostic significance has rarely been studied.
Soo Youn, Cho, Sang Yun, Ha, Song-Mei, Huang, Jeong Hoon, Kim, Myung Soo, Kang, Hae-Yong, Yoo, Hyeon-ho, Kim, Cheol-Keun, Park, Sung-Hee, Um, Kyung-Hee, Kim, Seok-Hyung, Kim   +10 more
openaire   +2 more sources

Requirement of Smad3 for mast cell growth

Cellular Immunology, 2006
The involvement of the TGF-beta family in cell growth of bone marrow-derived mast cells (BMMC) cultured with medium containing pokeweed mitogen-stimulated spleen cell-conditioned medium (PWM-SCM) was examined. Doubling time of BMMC from Smad3-null mice was longer than that from wild-type (WT) mice, and the differences tended to be larger with time of ...
Masayuki, Funaba, Kohei, Nakaya, Teruo, Ikeda, Masaru, Murakami, Kunihiro, Tsuchida, Hiromu, Sugino   +5 more
openaire   +2 more sources

Deletion of Smad3 prevents renal fibrosis and inflammation in type 2 diabetic nephropathy.

Metabolism: Clinical and Experimental, 2019
BACKGROUND Transforming growth factor (TGF)-β/Smad3 signaling is highly activated in kidneys of patients with type 2 diabetic nephropathy (T2DN), however, the precise role of Smad3 in the pathogenesis of diabetic nephropathy remains unclear.
Bi-Hua Xu, Jingyi Sheng, Y. You, Xiao-ru Huang, R. C. Ma, Qingwen Wang, H. Lan   +6 more
semanticscholar   +1 more source

LRNA9884, a Novel Smad3-Dependent Long Noncoding RNA, Promotes Diabetic Kidney Injury in db/db Mice via Enhancing MCP-1–Dependent Renal Inflammation

Diabetes, 2019
Transforming growth factor-β/Smad3 signaling plays an important role in diabetic nephropathy, but its underlying working mechanism remains largely unexplored.
Ying-ying Zhang, P. M. Tang, P. Tang, Jun Xiao, Xiao-ru Huang, Chen Yu, R. C. Ma, H. Lan   +7 more
semanticscholar   +1 more source