Results 241 to 250 of about 55,562 (295)

Activin A mitigates ferroptosis in cerebral ischemia/reperfusion injury via the PGC-1α/NRF1/TFAM axis. [PDF]

Front Neurol
Yang J, Shi X, Ma M, Li Z, Liu H, Cui Y, Xu Z, Wang J.   +7 more
europepmc   +1 more source

BRG1 exacerbates myocardial fibrosis after myocardial infarction by interacting with ZEB1. [PDF]

Front Pharmacol
Cui Y, Jin J, Cui Y, Ma Z, Tong T, Xiong L, Shen M, Zhao Y, Guo X, Liang W, Zhao H, Ban T, Huo R.   +12 more
europepmc   +1 more source

Opposing effects of Rho-associated coiled-coil kinase 1 (ROCK1) and ROCK2 in TGF-β-SMAD signaling. [PDF]

Cell Commun Signal
Bai Y, Ali MM, van Dinther M, Ten Dijke P, Moustakas A, Sundqvist A, Heldin CH.   +6 more
europepmc   +1 more source

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Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3/ATF3/SLC7A11 signaling.

Life Science, 2022
AIMS Chronic kidney disease (CKD) is characterized by interstitial fibrosis, while limited treatment drugs are available. Ferroptosis is a newly identified process that can trigger tubular atrophy and fibrosis. The aim of this study is to investigate the
Bing Zhu, Yufang Ni, Yi Gong, Xiaoshuang Kang, Huai-bin Guo, Xiaoheng Liu, Jianchun Li, Li Wang   +7 more
semanticscholar   +1 more source

Smad3 is required for enamel biomineralization

Biochemical and Biophysical Research Communications, 2003
Smad3 is an intracellular signaling molecule that mediates the signal from transforming growth factor-beta (TGF-beta) and activin receptors. In this study, we reveal hypomineralized enamel in mice with the targeted deletion of the Smad3 gene. The Smad3 (-/-) mice had chalky white incisor enamel, while the enamel of the wild-type or Smad3 (+/-) mice was
Chuxia Deng, Kunihiro Tsuchida, Keiji Moriyama   +2 more
exaly   +3 more sources

Ovarian Follicle Development Requires Smad3 [PDF]

Molecular Endocrinology, 2004
AbstractSmad3 is an important mediator of the TGFβ signaling pathway. Interestingly, Smad3-deficient (Smad3−/−) mice have reduced fertility compared with wild-type (WT) mice. To better understand the molecular mechanisms underlying the reduced fertility in Smad3−/− animals, this work tested the hypothesis that Smad3 deficiency interferes with three ...
Jodi Flaws, Woodruff Tk, Hilary Kenny
exaly   +3 more sources

Tectorigenin protects against unilateral ureteral obstruction by inhibiting Smad3‐mediated ferroptosis and fibrosis

Phytotherapy Research, 2021
Renal tubular epithelial cell (TEC) injury and fibrosis are the key factors of the pathogenesis of chronic kidney disease. Here, we reported that tectorigenin is effectively protected against obstructive nephropathy established by unilateral ureteral ...
Jianchun Li, Jie-ke Yang, Bing Zhu, Junming Fan, Qiongdan Hu, Li Wang   +5 more
semanticscholar   +1 more source

Smad3 and Smad3 Phosphoisoforms Are Prognostic Markers of Gastric Carcinoma

Digestive Diseases and Sciences, 2012
The transforming growth factor-β/Smads signaling pathway plays an important role in tumorigenesis and progression in cancer, and may closely be related to the biological behaviors of some malignant tumors, such as gastric carcinoma. In this study, we investigated the roles of Smad3 and Smad3 phosphoisoforms in the prognosis of gastric carcinoma.We ...
Seok-Hyung, Kim, Kyung-Hee, Kim, Soomin, Ahn, Jiyeon, Hyeon, Cheol-Keun, Park   +4 more
openaire   +2 more sources

Smad3 as a mediator of the fibrotic response [PDF]

International Journal of Experimental Pathology, 2004
SummaryTransforming growth factor‐β (TGF‐β) plays a central role in fibrosis, contributing to the influx and activation of inflammatory cells, the epithelial to mesenchymal transdifferentiation (EMT) of cells and the influx of fibroblasts and their subsequent elaboration of extracellular matrix.
exaly   +3 more sources

Nucleotide Sequence of Canine Smad3

Biochemical Genetics, 2009
The whole genome sequence of a Boxer dog suggested that the amino acid sequence of the carboxyl terminus of a putative Smad3 is SSVF-(COOH), not SSVS-(COOH) as in all Smad3 sequences identified in many species. Because phosphorylation of the last two serines at the carboxyl terminus is generally indispensable for Smad3-mediated signaling, the role of ...
Kazutoshi, Sugiyama, Ryo, Ooishi, Yoshii, Nishino, Masayuki, Funaba, Masaru, Murakami   +4 more
openaire   +2 more sources