Results 191 to 200 of about 1,611,169 (342)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

A High-Performance Self-Collimation SPECT for Small Animal Imaging. [PDF]

IEEE Trans Med Imaging
Zhang D, Lyu Z, Xu T, Fan P, Yu Z, Ye Q, Hu Y, Wu J, Wei Q, Zhang X, Gan Q, Xu Y, Wang L, Yao R, Yang MF, He ZX, Liu Y, Ma T.   +17 more
europepmc   +1 more source

Persistent luminescence tomography for small animal imaging. [PDF]

Biomed Opt Express, 2017
Cao X, Gong Y, Li Y, Zhu S, Zhang X, Zhan Y, Kang F, Wang J, Liang J.   +8 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Development of anatomically variable digital Wistar rat phantoms for small animal imaging research. [PDF]

Med Phys
Segars HE, Nadkarni R, Badea CT, Badea A, Chin B, Johnson GA, Payne J, Samei E, Segars WP.   +8 more
europepmc   +1 more source

Task-based design of a synthetic-collimator SPECT system used for small animal imaging. [PDF]

Med Phys, 2018
Lin A, Kupinski MA, Peterson TE, Shokouhi S, Johnson LC.   +4 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Magnetic resonance coil prototyping and implementation for multi-nuclear small animal imaging. [PDF]

J Magn Reson Open
Zavriyev AI, Yoon BJ, Choi J, Adebesin BY, Jacobs PS, Mizsei G, Sheehan MM, Kadlecek S, Gade TPF.   +8 more
europepmc   +1 more source

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial. [PDF]

PLoS One, 2019
Blocker SJ, Mowery YM, Holbrook MD, Qi Y, Kirsch DG, Johnson GA, Badea CT.   +6 more
europepmc   +1 more source