Results 111 to 120 of about 64,324 (310)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

From vulnerable to resilience: an assessment of small-scale fisheries livelihood in South Malang of Indonesia

Discover Sustainability
The livelihoods of small-scale fisheries in South Malang of Indonesia are being notably influenced by ecosystem degradation and climate change. Therefore, this study aims to investigate the vulnerability of small-scale fisheries in South Malang of ...
Puji Handayati, Ahmad Munjin Nasih, Indah Susilowati, Idris, Prateep Kumar Nayak, Bagus Shandy Narmaditya   +5 more
doaj   +1 more source

Provisioning ecosystem services through the sustainable management of fish resources extracted by small-scale fishers [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: As an urban coastal, Jakarta Bay faces significant pressure from human activities. Such pressure may result in the degradation of fish resources.
E. Yuliana, M. Nurilmala, A. Rahadiati, I. Farida, H. Kurniawati, S. Agustina, D.A. Difah, P.R. Pertiwi, B.E. Wicaksana, R.V. Ramillo, W.A. Djatmiko   +10 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Envisioning desirable futures in small-scale fisheries: a transdisciplinary arts-based co-creation process

Ecology and Society
Despite the critical importance of small-scale fisheries for food security and well-being and the role of fishers as stewards of aquatic ecosystems, their future is uncertain. Tackling narratives that portray small-scale fisheries as obsolete, disparate,
Ignacio Gianelli, Micaela Trimble, Silvana Juri, Nazarena A. Beretta, Denisse Torena, Manuela Acosta, Robert Acosta, Mario Del Bó, Jorge A. Fuster, Vanessa González, Diego Kurta, Marcelo Kurta, Tamara López, María E. Marfetán, Pablo Montes de Oca, Alberto Morales, Victoria Pardo, Juan Sandoval, Nancy Schuch, Claudio Taroco, Albert V. Norström, Laura M. Pereira, Sebastián Villasante   +22 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Small-scale capture fisheries: a global overview with emphasis on developing countries: a preliminary report of the Big Numbers Project [PDF]

The report gives a summary of the results to-date of case studies carried out in a selected number of countries which provides a first analysis of the differences between marine and inland small and large scale fisheries in developing countries.
Food and Agriculture Organization of the United Nations, WorldFish Center   +1 more
core  

Promoting governability in small-scale capture fisheries in the Persian Gulf: The case of Qeshm Island [PDF]

, 2020
Source at http://jifro.ir/index.php?slc_lang=en&sid=1.The present study examines the fisheries governance status of small-scale capture fisheries in the northern Persian Gulf.
Kamrani, E., Daliri, M., Jentoft, Svein
core