Results 121 to 130 of about 64,324 (310)

Mapping place names for small-scale fisheries evaluation

Aquatic Living Resources
Fishers’ spatial knowledge encompasses a diverse array of social, ecological, technical, experiential, and learning knowledge derived from local environmental and sociocultural contexts.
Randriatsara Roddy M., Behivoke Faustinato, Ramahatratra Frédéric, Mahafina Jamal, Lamy Thomas, Léopold Marc   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Handbook Socioeconomic Data Collection in Small-scale Fisheries (Based on SEAFDEC Experiences) [PDF]

The handbook “Socioeconomic Data Collection in Small-scale Fisheries” was developed based on SEAFDEC’s experiences and contributions from resource persons at Kasetsart University, Prince of Songkla University, the Department of Fisheries, Thailand, and ...

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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Intersecting relational perspectives to understand fishery trade chain dynamics: the case of Magweva in KaNyaka Island, Mozambique

Ecology and Society
Trade relations in small-scale fisheries have long been studied as more than economic exchanges. Relational economic sociology and relational economic geography have shown the importance of social relations and space in understanding trade relations.
María Mancilla García, Elizabeth Drury O'Neill, Tilman Hertz, Taís Sonetti-González, Marlino E Mubai, Dadivo J Combane, Tim M Daw, Salomão Bandeira   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Why fish? Using entry-strategies to inform governance of the small-scale sector: A case-study in the Bijagós Archipelago (West Africa) [PDF]

, 2015
Should rural commercial small-scale fishing opportunities be closed to minimise effort and safeguard marine resources or open to offer livelihood support?
Cross, H
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Nurturing sustainable small-scale fisheries to strengthen food sovereignty in Qikiqtarjuaq, Nunavut, Canada

Arctic Science
For generations, Inuit in Nunavut have relied on small-scale fisheries as a foundation for food security, cultural identity, and economic resilience. However, systemic barriers, such as the high cost of living, limited infrastructure, climate change, and
Meghan Brockington, Tiff-Annie Kenny, Mélanie Lemire, Hing Man Chan, Dennis Nauyavik, Philip Loring, Jane Parmley, Matthew Little   +7 more
doaj   +1 more source

Managing small-scale commercial fisheries for adaptive capacity: insights from dynamic social-ecological drivers of change in Monterey Bay.

PLoS ONE, 2015
Globally, small-scale fisheries are influenced by dynamic climate, governance, and market drivers, which present social and ecological challenges and opportunities.
Stacy E Aguilera, Jennifer Cole, Elena M Finkbeiner, Elodie Le Cornu, Natalie C Ban, Mark H Carr, Joshua E Cinner, Larry B Crowder, Stefan Gelcich, Christina C Hicks, John N Kittinger, Rebecca Martone, Daniel Malone, Carrie Pomeroy, Richard M Starr, Sanah Seram, Rachel Zuercher, Kenneth Broad   +17 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source