Results 101 to 110 of about 9,855,827 (301)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Small-scale Fisheries in the Southeast Asian Region

open access: yes, 2010
In the Southeast Asian region, fisheries is considered one of the very important sectors contribution to the development of national economy, income generation, employment opportunity, livelihood, and food security for the people.

core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Managing small-scale commercial fisheries for adaptive capacity: insights from dynamic social-ecological drivers of change in Monterey Bay.

open access: yesPLoS ONE, 2015
Globally, small-scale fisheries are influenced by dynamic climate, governance, and market drivers, which present social and ecological challenges and opportunities.
Stacy E Aguilera   +17 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Unlocking legal and policy frameworks for small-scale fisheries in Australia

open access: yes, 2022
The purpose of this book is to encourage countries to take the required steps in appraising the extent to which the current fisheries legislation and policies are applicable for small-scale fisheries governance, and in expanding this analysis to other ...
Sbrocchi, C   +3 more
core  

Envisioning desirable futures in small-scale fisheries: a transdisciplinary arts-based co-creation process

open access: yesEcology and Society
Despite the critical importance of small-scale fisheries for food security and well-being and the role of fishers as stewards of aquatic ecosystems, their future is uncertain. Tackling narratives that portray small-scale fisheries as obsolete, disparate,
Ignacio Gianelli   +22 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Small-scale capture fisheries: a global overview with emphasis on developing countries: a preliminary report of the Big Numbers Project [PDF]

open access: yes
The report gives a summary of the results to-date of case studies carried out in a selected number of countries which provides a first analysis of the differences between marine and inland small and large scale fisheries in developing countries.
Food and Agriculture Organization of the United Nations   +1 more
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

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