Results 101 to 110 of about 64,324 (310)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Past and future impacts of marine heatwaves on small-scale fisheries in Baja California, Mexico

Communications Earth & Environment
Marine heatwaves are globally occurring events that can negatively impact fisheries, but their impacts on small-scale operations remain understudied. We investigate the historical and future impacts of marine heatwaves on small-scale fisheries operating ...
Juan Carlos Villaseñor-Derbez, Nur Arafeh-Dalmau, Fiorenza Micheli   +2 more
doaj   +1 more source

Fishers and groupers (Epinephelus marginatus and E. morio) in the coast of Brazil: integrating information for conservation

Journal of Ethnobiology and Ethnomedicine, 2019
Background Groupers are a vulnerable but economically important group of fish, especially for small-scale fisheries. We investigated catches and local ecological knowledge (LEK) of diet, habitat, and past fishing experiences.
Alpina Begossi, Svetlana Salyvonchyk, Branko Glamuzina, Shirley Pacheco de Souza, Priscila F. M. Lopes, Regina H. G. Priolli, Djalma Osmanir do Prado, Milena Ramires, Mariana Clauzet, Cleverson Zapelini, Daiana T. Schneider, Luis T. Silva, Renato A. M. Silvano   +12 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Small-scale fisheries of San Miguel Bay, Philippines: biology and stock assessment [PDF]

Small scale fisheries, Fishery biology, Fishery resources, Stock assessment, Collected papers, San Miguel Bay, Philippines,
Mines, A.N. (eds.), Pauly, D.
core  

Promotion of Small-scale Inland Fisheries Community-based Management and Co-management [PDF]

, 2018
Poster of Promotion of Small-scale Inland Fisheries Community-based Management and Co ...
Southeast Asian Fisheries Development Center, Training Department
core  

Fisheries local action groups, small‐scale fisheries and territorial development

Sociologia Ruralis
AbstractIn comparison to the wealth of critical evaluation of LEADER (i.e., Liaison entre actions de développement de l'économie rurale), there has been no consolidated attempt to reflect on the contribution of Fisheries Local Action Groups (FLAGs), now entering their third EU programming period.
Jeremy Phillipson, Pekka Salmi, Sebastian Linke, Kristina Svels, Urszula Budzich‐Tabor   +4 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A research framework for traditional fisheries [PDF]

Small scale fisheries, Fisheries ...
Smith, I.R.
core  

Temporal and seasonal influences concerning the carbon footprint of pelagic fisheries [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Pelagic fisheries play a vital role in sustaining coastal livelihoods and food security in the Eastern Indian Ocean, yet they also contribute to greenhouse gas emissions due to fuel-intensive operations.
Syamdidi ,, M.R. Putri, L.I. Bernawis, R.A. Wahyudin, S.W. Trenggono, S.D. Diantara, T. Yuwono, W.I. Sakti, F.Y. Arthatiani, D.C. Simamora, A. Sabina, L.O.M.A. Wahid, I.N. Radiarta, K. Kasim   +13 more
doaj   +1 more source