Results 81 to 90 of about 9,855,827 (301)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Small-scale fisheries of San Miguel Bay, Philippines: social aspects of production and marketing [PDF]

Small scale fisheries, Sociological aspects, Marketing, Women, Fishermen, San Miguel Bay, Philippines,
Bailey, C. (ed.)
core  

The Contested Commons: The Failure of EU Fisheries Policy and Governance in the Mediterranean and the Crisis Enveloping the Small-Scale Fisheries of Malta

Frontiers in Marine Science, 2018
This paper highlights how multi-scalar interstitial policy failings of the EU fisheries policy can directly trigger policy gaps in fisheries management at the expense of artisanal communities, leading to further expansion opportunities for industrial ...
Alicia Said, Alicia Said, Joseph Tzanopoulos, Joseph Tzanopoulos, Douglas MacMillan   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Characteristics of the shark fisheries of Fiji [PDF]

, 2015
Limited information is available on artisanal and subsistence shark fisheries across the Pacific. The aim of this study was to investigate Fiji’s inshore fisheries which catch sharks.
Adrian-Kalchhauser, I., Brunnschweiler, J. M., Burkhardt-Holm, P., White, W. T., Glaus, K. B. J.   +4 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Small-scale fisheries of San Miguel Bay, Philippines: biology and stock assessment [PDF]

Small scale fisheries, Fishery biology, Fishery resources, Stock assessment, Collected papers, San Miguel Bay, Philippines,
Mines, A.N. (eds.), Pauly, D.
core  

Fishers and groupers (Epinephelus marginatus and E. morio) in the coast of Brazil: integrating information for conservation

Journal of Ethnobiology and Ethnomedicine, 2019
Background Groupers are a vulnerable but economically important group of fish, especially for small-scale fisheries. We investigated catches and local ecological knowledge (LEK) of diet, habitat, and past fishing experiences.
Alpina Begossi, Svetlana Salyvonchyk, Branko Glamuzina, Shirley Pacheco de Souza, Priscila F. M. Lopes, Regina H. G. Priolli, Djalma Osmanir do Prado, Milena Ramires, Mariana Clauzet, Cleverson Zapelini, Daiana T. Schneider, Luis T. Silva, Renato A. M. Silvano   +12 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Past and future impacts of marine heatwaves on small-scale fisheries in Baja California, Mexico

Communications Earth & Environment
Marine heatwaves are globally occurring events that can negatively impact fisheries, but their impacts on small-scale operations remain understudied. We investigate the historical and future impacts of marine heatwaves on small-scale fisheries operating ...
Juan Carlos Villaseñor-Derbez, Nur Arafeh-Dalmau, Fiorenza Micheli   +2 more
doaj   +1 more source