Results 71 to 80 of about 9,855,827 (301)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 1992 The SEAFDEC Training Department has conducted regional training programs for fishery extension officers, with assistance from the Royal Netherlands Government under the Netherlands the Programme for Studies in the Region (SIR/DSO), since 1981.
Southeast Asian Fisheries Development Center, Training Department
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Report of the Regional Workshop Towards a New Era of Support for Small-scale Fisheries in Southeast Asia [PDF]
, 2023 The Regional Workshop on Towards a New Era of Support for Small-scale Fisheries in Southeast Asia was organized on 29‒31 August 2023. The Workshop was aimed at 1) compiling the description/recognition/contribution of SSF in the region (or in each country)
Training Department, Southeast Asian Fisheries Development Center
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Small-scale fisheries of San Miguel Bay, Philippines: economics of production and marketing [PDF]
Small scale fisheries, Fishery economics, Marketing, Collected papers, San Miguel Bay, Philippines,
Mines, A.N. (eds.), Smith, I.R.
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Small-scale fisheries of San Miguel Bay, Philippines: options for management and research [PDF]
Small scale fisheries, Fishery management, San Miguel Bay, Philippines,
Pauly, D., Mines, A.N., Smith, I.R.
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Drivers of fishing at the household scale in Fiji
Ecology and Society, 2018 Coral reefs sustain millions of people worldwide, yet in recent years, social, environmental, and climate change have caused major declines in coral reef fisheries.
Rachel Dacks +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Mapping social-ecological connectivity of small scale fisheries: A network-based study in Paraja Bay, Banten, Indonesia [PDF]
BIO Web of ConferencesThe small-scale fisheries of Paraja Bay are a complex system that plays a vital role in people's livelihoods. This study aims to map the connectivity of social-ecological components in small-scale fisheries systems in Paraja Bay, Banten, Indonesia ...
Choiri Muhamad Fatin +2 more
doaj +1 more source