Results 51 to 60 of about 303,059 (302)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Determinants of fish catch and post-harvest fish spoilage in small-scale marine fisheries in the Bagamoyo district, Tanzania

Heliyon, 2022
The fisheries sector of Tanzania is dominated by small-scale fishers who produce up to 95% of the total amount of fish caught in the country. The small-scale fisheries are constrained by inadequate infrastructure, including a lack of capacity for ...
Rosemary Peter Mramba, Kelvin Emmanuel Mkude   +1 more
doaj   +1 more source

Ecosystem Approach to Small Scale Tropical Marine Fisheries [PDF]

, 2013
This is a 4-page brochure about a WorldFish led project. Throughout the world, poor fisheries management contributes to resource degradation, poverty, and food insecurity.
E. Kamanyi, K. Brown, L. Evans, R. Mwaipopo, T. Daw, W. Haule, Y. Mgaya   +6 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Limits to fishing: the case for collective self-limitation illustrated with an example of small-scale fisheries in Catalonia

Frontiers in Marine Science, 2023
Is there a limit to the amount of fish that can be taken from the sea? This question echoes the concern of the broader environmental movement in asking: are there ‘limits to growth’?
Borja Nogué-Algueró, Giorgos Kallis, Giorgos Kallis, Miquel Ortega   +3 more
doaj   +1 more source

Towards Sustainable Development of Small-Scale Fisheries in the Philippines: Experiences and Lessons Learned from Eight Regional Sites [PDF]

, 2012
The focus of this paper is on the governance of small-scale or municipal fisheries in the Philippines in light of the critical role they play in the livelihoods of coastal communities and in the nation as a whole.
L. R. Garces, M. D. Pido, M. L. Perez, N. D. Salayo   +3 more
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Analytical Appendix 2: The Challenges of Managing Small Scale Fisheries in West Africa [PDF]

, 2004
This is the Final Technical Report to the DFID regarding The Management of Conflict in Tropical Fisheries project R7334. Ghana's small-scale marine fisheries face considerably less problems and challenges than its neighbours.
E. Bennett
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The role of certifications and eco-labels in fisheries: a systematic literature review of their benefits and challenges

Environmental Sciences Europe
Eco-labels are market tools that provide consumers with relevant information, enabling more informed and sustainable purchasing decisions. As fisheries operate on a high production scale, it is possible to dilute the costs of implementing and maintaining
Marília Tenório Gouveia de Melo, Jheyce Milena da Silva Barros, Ana Regina Bezerra Ribeiro, Telma Lucia de Andrade Lima, Marcos Felipe Falcão Sobral   +4 more
doaj   +1 more source