Results 61 to 70 of about 302,867 (282)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Social and temporal dynamics mediate the distribution of ecosystem service benefits from a small-scale fishery

Ecosystems and People, 2022
Small-scale fisheries are important for the livelihoods and food security of millions of people in low-income countries. Sustainably managing these dynamic social-ecological systems requires understanding links between ecosystems and human well-being ...
R. Grantham, J. Lau, D. J. Mills, G. S. Cumming   +3 more
doaj   +1 more source

Regional Fisheries Livelihoods Programme for South and Southeast Asia (RFLP) Activity 1.5 (2011): Systems and Procedures for Participatory Monitoring of Management Measures Developed, Introduced and Implemented-catch Monitoring [PDF]

, 2012
Coastal fisheries are very essential for supporting the livelihoods of many rural poor in the coastal areas, particularly coastal community fisheries members.
Kong Heng, Peng Bun Ngor
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Contributions of small‐scale and longline fishing to sea turtle mortality in the Solomon Islands

Conservation Letters
A focus of sea turtle management has been reducing bycatch in commercial fisheries, but sustainable harvest for consumption is also an important objective in many nations. Identifying how much different fisheries contribute to turtle mortality could help
Christopher Brown, Richard Hamilton, Simon Vuto, Willie Atu, Rosalie Masu, Christain Ramofafia, Pete Waldie   +6 more
doaj   +1 more source

Women and Children First: the Gendered and Generational Social-ecology of Smaller-scale Fisheries in Newfoundland and Labrador and Northern Norway

Ecology and Society, 2013
The resilience of small-scale fisheries in developed and developing countries has been used to provide lessons to conventional managers regarding ways to transition toward a social-ecological approach to understanding and managing fisheries.
Barbara Neis, Siri Gerrard, Nicole G. Power   +2 more
doaj   +1 more source

Spawning potential surveys in Fiji: A new song of change for small‐scale fisheries in the Pacific

Conservation Science and Practice, 2021
Catastrophic overfishing of small‐scale coastal fisheries through the Pacific poses a major threat to regional food security and biodiversity. Globally, approaches to fisheries assessment and management that were developed for industrial fisheries, are ...
Jeremy Prince, Watisoni Lalavanua, Jone Tamanitoakula, Laitia Tamata, Stuart Green, Scott Radway, Epeli Loganimoce, Tevita Vodivodi, Kalisiana Marama, Pitila Waqainabete, Frank Jeremiah, Diana Nalasi, Mosese Naleba, Waisea Naisilisili, Uraia Kaloudrau, Lepani Lagi, Kalisiana Logatabua, Rosemary Dautei, Rahul Tikaram, James Sloan, Sangeeta Mangubhai   +20 more
doaj   +1 more source

Untangling Conflicts in Small‐Scale Fisheries [PDF]

Fish and Fisheries
ABSTRACTConflicts are presumably pervading small‐scale fishery (SSF) systems around the world due to the highly complex interactions taking place within them. To provide a deeper understanding of these conflicts and the resolution strategies in place, a literature review was conducted.
Almudena Cánovas Molina, Sophie Gourguet   +1 more
openaire   +1 more source

Diagnosis and the management constituency of small-scale fisheries [PDF]

, 2009
Diagnosis and adaptive management can help improve the ability of small-scale fisheries (SSF) in the developing world to better cope with and adapt to both external drivers and internal sources of uncertainty.
Andrew, N., Evans, L.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source