Results 71 to 80 of about 302,867 (282)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Drivers of fishing at the household scale in Fiji

Ecology and Society, 2018
Coral reefs sustain millions of people worldwide, yet in recent years, social, environmental, and climate change have caused major declines in coral reef fisheries.
Rachel Dacks, Tamara Ticktin, Stacy D. Jupiter, Alan Friedlander   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Mapping social-ecological connectivity of small scale fisheries: A network-based study in Paraja Bay, Banten, Indonesia [PDF]

BIO Web of Conferences
The small-scale fisheries of Paraja Bay are a complex system that plays a vital role in people's livelihoods. This study aims to map the connectivity of social-ecological components in small-scale fisheries systems in Paraja Bay, Banten, Indonesia ...
Choiri Muhamad Fatin, Yulianto Gatot, Boer Mennofatria   +2 more
doaj   +1 more source

Fisheries local action groups, small‐scale fisheries and territorial development

Sociologia Ruralis
AbstractIn comparison to the wealth of critical evaluation of LEADER (i.e., Liaison entre actions de développement de l'économie rurale), there has been no consolidated attempt to reflect on the contribution of Fisheries Local Action Groups (FLAGs), now entering their third EU programming period.
Jeremy Phillipson, Pekka Salmi, Sebastian Linke, Kristina Svels, Urszula Budzich‐Tabor   +4 more
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

The Contested Commons: The Failure of EU Fisheries Policy and Governance in the Mediterranean and the Crisis Enveloping the Small-Scale Fisheries of Malta

Frontiers in Marine Science, 2018
This paper highlights how multi-scalar interstitial policy failings of the EU fisheries policy can directly trigger policy gaps in fisheries management at the expense of artisanal communities, leading to further expansion opportunities for industrial ...
Alicia Said, Alicia Said, Joseph Tzanopoulos, Joseph Tzanopoulos, Douglas MacMillan   +4 more
doaj   +1 more source

Small-scale capture fisheries: a global overview with emphasis on developing countries: a preliminary report of the Big Numbers Project [PDF]

The report gives a summary of the results to-date of case studies carried out in a selected number of countries which provides a first analysis of the differences between marine and inland small and large scale fisheries in developing countries.
Food and Agriculture Organization of the United Nations, WorldFish Center   +1 more
core  

Strengthening Governance of Small-Scale Fisheries: An Initial Assessment of the Theory and Practice [PDF]

, 2017
Preferred citation for this report: Basurto, X., Virdin, J., Smith, H. and R. Juskus. 2017. Strengthening Governance of Small-Scale Fisheries: An Initial Assessment of Theory and Practice.
H. Smith, J. Virdin, R. Juskus, X. Basurto   +3 more
core