Results 71 to 80 of about 303,059 (302)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Drivers of fishing at the household scale in Fiji

Ecology and Society, 2018
Coral reefs sustain millions of people worldwide, yet in recent years, social, environmental, and climate change have caused major declines in coral reef fisheries.
Rachel Dacks, Tamara Ticktin, Stacy D. Jupiter, Alan Friedlander   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Mapping social-ecological connectivity of small scale fisheries: A network-based study in Paraja Bay, Banten, Indonesia [PDF]

BIO Web of Conferences
The small-scale fisheries of Paraja Bay are a complex system that plays a vital role in people's livelihoods. This study aims to map the connectivity of social-ecological components in small-scale fisheries systems in Paraja Bay, Banten, Indonesia ...
Choiri Muhamad Fatin, Yulianto Gatot, Boer Mennofatria   +2 more
doaj   +1 more source

Fisheries local action groups, small‐scale fisheries and territorial development

Sociologia Ruralis
AbstractIn comparison to the wealth of critical evaluation of LEADER (i.e., Liaison entre actions de développement de l'économie rurale), there has been no consolidated attempt to reflect on the contribution of Fisheries Local Action Groups (FLAGs), now entering their third EU programming period.
Jeremy Phillipson, Pekka Salmi, Sebastian Linke, Kristina Svels, Urszula Budzich‐Tabor   +4 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The Contested Commons: The Failure of EU Fisheries Policy and Governance in the Mediterranean and the Crisis Enveloping the Small-Scale Fisheries of Malta

Frontiers in Marine Science, 2018
This paper highlights how multi-scalar interstitial policy failings of the EU fisheries policy can directly trigger policy gaps in fisheries management at the expense of artisanal communities, leading to further expansion opportunities for industrial ...
Alicia Said, Alicia Said, Joseph Tzanopoulos, Joseph Tzanopoulos, Douglas MacMillan   +4 more
doaj   +1 more source

Small-scale capture fisheries: a global overview with emphasis on developing countries: a preliminary report of the Big Numbers Project [PDF]

The report gives a summary of the results to-date of case studies carried out in a selected number of countries which provides a first analysis of the differences between marine and inland small and large scale fisheries in developing countries.
Food and Agriculture Organization of the United Nations, WorldFish Center   +1 more
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