Results 41 to 50 of about 5,772,088 (305)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Revista Criminalidad, 2010 Este documento tiene como objetivo realizar una exploración de los datos provenientes de diferentes fuentes sobre violencia relacionada con armas de fuego, con el fin de visibilizar el impacto que estas han tenido en la población colombiana durante las ...
Katherine Aguirre
doaj
Heraldry in Macedonia with Special Regard to the People’s/Socialist Republic of Macedonia until 1991
Genealogy, 2021 Every European region and country has some specific heraldry. In this paper, we will consider heraldry in the People’s/Socialist Republic of Macedonia, understood by the multitude of coats of arms, and armorial knowledge and art.
Jovan Jonovski
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Small Arms and Light Weapons: new round of contradictions
Vestnik MGIMO-Universiteta, 2010 Пару десятилетий тому назад Фрэнсис Фукуяма предрек «конец истории», и ошибся. Именно в те годы история, образно говоря, начинала свой новый отсчет, но несколько в ином направле- нии, чем виделось американскому ученому.
A. A. Orlov
doaj +1 more source
Firing blanks? The Arms Trade Treaty [PDF]
, 2014 This paper assesses key provisions of the ATT by first back-grounding its origins and contested formulation before assessing its transfer, prohibition and national control provisions, Introduction The Arms Trade Treaty (ATT) was adopted by vote at the ...
Roderic Alley
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
International Studies Journal, 2023 The research work focus on the origin and brief history of Esanland in Edo State. This study examined proliferation of small arms and it impact on nation building in Esanland with special focus on Uraomi from 1970-1991.
Esezobor Paul, Fidelis Achoba
doaj