Results 61 to 70 of about 5,772,088 (305)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Oñati Socio-Legal Series, 2013 A hallmark of contemporary global governance is its complex nature. Understanding the implications of the array of “governors” and their efforts is paramount for scholars of global law and global politics.
Deborah Avant
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
KAS African Law Study Library, 2016 This paper reflects on making ang holdingSmall Arms and Light Weapons in DRC. It ar- gues that the Small Arms and Light Weapons legal framework in Congo DRC needs reform in order to respond to international and regional rules and increasing the national ...
BAHELLABY Timothée
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Under Fire: The human cost of small arms in north-east Democratic Republic of the Congo [PDF]
, 2001 The ongoing conflict in the east of the Democratic Republic of the Congo has been described as one of the world's worst humanitarian crises. It is a war mainly fought out with small arms.
core +1 more source
Energies, 2019 Most vertical axis wind turbines (VAWTs) need arms connecting the blades with the rotational axis. The arms increase the power loss of VAWTs; however, the distribution between the pressure and friction influences and their degrees of influence have not ...
Yutaka Hara +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Chinese Journal of Lung Cancer, 2014 Background and objective Epidermal growth factor receptor (EGFR) inhibitors are mainly used for the targeted therapy of non-small cell lung cancer (NSCLC). Therefore, EGFR mutations should be detected to treat lung cancer.
Chenchen LI +3 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source