Results 61 to 70 of about 1,353,263 (305)

5.56mm or 7.62mm? Small Arms Alternatives Explored. [PDF]

, 2012
Small arms developments tend to occur in cycles and decisions are made that influence events for tens of years ahead. The ‘boots on the ground,’ from both the US and UK, have recently been voicing concern about aspects such as system mechanical ...
Phil Harrison
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Infiltration of Small Arms and Light Weapons into Benue Valley and Its Impact on the Conflict Between Pastoralists and Farmers

International Studies Journal, 2023
One of the challenges confronting nation states is the proliferation of small arms and light weapons. This problem is more pronounce in developing countries where there are porous borders and weak institutions responsible for border security like ...
Paulina Ada Akpa, Terver Akpar, Samson Aondowase Fada   +2 more
doaj  

ALMA resolves the spiraling accretion flow in the luminous OB cluster forming region G33.92+0.11

, 2015
How rapidly collapsing parsec-scale massive molecular clumps feed high-mass stars, and how they fragment to form OB clusters, have been outstanding questions in the field of star-formation.
Chen, Huei-Ru, Galván-Madrid, Roberto, Jiménez-Serra, Izaskun, Li, Zhiyun, Liu, Hauyu Baobab, Román-Zúñiga, Carlos, Zhang, Qizhou   +6 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Shape and orientation of stellar velocity ellipsoids in spiral galaxies [PDF]

, 2007
We present a numerical study of the properties of the stellar velocity distribution in stellar discs which have developed a saturated, two-armed spiral structure.
Alcobé, Athanassoula, Bertin, Bienaymé, Binney, Binney, Blitz, Carlberg, Ch. Theis, Cuddeford, De Simone, Dehnen, Dehnen, Dehnen, Dehnen, E. I. Vorobyov, Eddington, ESA, Freeman, Gerssen, Goldreich, Hogg, Jenkins, Julian, Kaufmann, Kerr, Kobold, Kuijken, Kuijken, Lin, Mayor, Mayor, Minchev, Minchev, Minchev, Mühlbauer, Patsis, Polyachenko, Ratnatunga, Schwarzschild, Spitzer, Toomre, Vorobyov, Wielen, Wielen, Yuan   +45 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Evidence for the Large-Scale Dissociation of Molecular Gas in the Inner Spiral Arms of M81 [PDF]

, 1997
We compare the detailed distributions of HI, H alpha, and 150 nm far-UV continuum emission in the spiral arms of M81 at a resolution of 9" (linear resolution 150 pc at 3.7 Mpc distance).
Bloemen J. B., Brouillet N., Israel F. P., J. H. Knapen, Knapen J. H., Loinard L., Petit H., R. Bohlin, R. J. Allen, Seaton M. J., T. P. Stecher, Tilanus R. P. J., Tilanus R. P. J., van der Kruit P. C.   +13 more
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source