Results 221 to 230 of about 10,866,941 (342)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Advanced gastric small cell carcinoma with immunotherapy-based treatment: A case report. [PDF]

World J Gastrointest Oncol
Zhang XL, Zhang JY, Xie L, Li H, Wang L.
europepmc   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Chemotherapy response in primary peritoneal small cell carcinoma. [PDF]

Discov Oncol
Alqasem K, Alshwayyat S, Aljawabrah S, Nser SY, Eqleem A, Abu Shattal M, Hajir M, Al-Kurdi MA.   +7 more
europepmc   +1 more source

Morphological CT and MRI characteristics of small cell neuroendocrine bladder cancers and their predictive factors for distinguishing from conventional urothelial carcinoma

Mingmei Wang, Yuan Luo, Jianpeng Li, Zhiqiang Bai, Zhuoheng Yan, Fengqiong Huang, Longfeng Yang, Abuduxukuer Aili, Yong Li, Xiaohui Duan   +9 more
openalex   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Gallbladder small cell carcinoma from chronic cholecystitis: A case report and review of literature. [PDF]

World J Gastrointest Surg
Yu JQ, He XS, Xue YZ, Hu LY, Wen X, Yang XD, Zhou X.   +6 more
europepmc   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Association of surgery with survival in small cell carcinoma of the digestive system: a population-based observational study using machine learning. [PDF]

Sci Rep
Huang K, Huang Z, He Y, Zhao P, Hu X.
europepmc   +1 more source

Two Cases of Uterine Small-cell Neuroendocrine Carcinoma With Somatostatin-receptor-type-2 (SSTR2) Expression and Minor Components of Endocervical Adenocarcinoma

Masamichi Bamba, Tomo Namura, T. Kato, Masanori Shiohara, Kenji Isogawa, Mao Uemura, Shiro Wakinoue, Hiroko Yomo, Tetsuya Nakagawa, Tetsuya Katsumori, Ryoji Kushima, Suzuko Moritani   +11 more
openalex   +2 more sources