Results 121 to 130 of about 29,200,069 (297)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

An Educational Interventional Study to Compare the Effectiveness of Small Group Discussion Versus Role Play as a Teaching Learning Method in the Subject of Pharmacology

Graduate Medical Education Research Journal
Background: Teaching-learning methods include lectures, discussions, and small group activities. Small group discussions and role-plays enhance adult learning by promoting participation, reflection, communication, and teamwork.
Akanksha Prajapati, Alay Patel, Rupal Shah, Vipul Chaudhari   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

son Of Performance And Perception Of Undergraduate Medical Students Towards Different Small Group Teaching Strategies

Journal of Rawalpindi Medical College
Objective: The objective of this study is to evaluate the perception of students towards the effectiveness of small group teaching methods in pathology and to determine their performance in them.
Maryam Habib, Ghazala Mudassir, Mahwish Majid Bhatti, Rifat Nadeem Ahmad   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

PERCEPTION OF MBBS STUDENTS ON SMALL GROUP DISCUSSION VERSUS LECTURE AS LEARNING METHODS IN COMPETENCY-BASED MEDICAL EDUCATION

Genetics and Molecular Research
Background: Competency-Based Medical Education (CBME) emphasizes learner-centered, interactive teaching strategies to promote higher-order competencies among undergraduate medical students. Small Group Discussions (SGDs) have increasingly been integrated alongside traditional lectures; however, student perception remains a critical indicator of their ...
Dr. Vaishnavi Ranga, Dr. Niveditha Prasanth, Prof. Dr. TS Meena   +2 more
openaire   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

The effectiveness of small group discussion in writing report text

Lack of interest in writing individually by students makes writing activity as one of the four language skills pay less attention to the students. Creating small Group Discussion is one method that can help students improve their learning achievement ...
Setiawan, Ari, Sari, Ika Purnama, Siregar, Epi Supriyani, Roslaini, Roslaini, Khairas, Eri Ester, Muljo, Ariyani   +5 more
core   +1 more source