Results 1 to 10 of about 7,610,404 (354)

The small GTPase MRAS is a broken switch [PDF]

Nature Communications
Intense research on founding members of the RAS superfamily has defined our understanding of these critical signalling proteins, leading to the premise that small GTPases function as molecular switches dependent on differential nucleotide loading.
Gabriela Bernal Astrain, Regina Strakhova, Chang Hwa Jo, Emma Teszner, Ryan C. Killoran, Matthew J. Smith   +5 more
doaj   +2 more sources

Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions [PDF]

Frontiers in Physiology, 2023
The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
doaj   +2 more sources

The small GTPase Rho5-Yet another player in yeast glucose signaling. [PDF]

PLoS Genetics
The small GTPase Rho5 has been shown to be involved in regulating the Baker's yeast response to stress on the cell wall, high medium osmolarity, and reactive oxygen species.
Franziska Schweitzer, Linnet Bischof, Stefan Walter, Silke Morris, Hans-Peter Schmitz, Jürgen J Heinisch   +5 more
doaj   +2 more sources

Small GTPase ARL4C Associated with Various Cancers Affects Microtubule Nucleation [PDF]

Biomedicines
Background/Objectives: The changes in the level of small GTPase ARL4C are associated with the initiation and progression of many different cancers. The content of ARL4C varies greatly between different tissues, and the induction of ARL4C expression leads
Evgeniia Ulas, Ilya Brodsky, Anton Burakov   +2 more
doaj   +2 more sources

Integrated Analysis of the Anoikis-Related Signature Identifies Rac Family Small GTPase 3 as a Novel Tumor-Promoter Gene in Hepatocellular Carcinoma. [PDF]

MedComm (2020)
Wu D, Liu ZK, Sun Y, Gou CH, Shang RZ, Lu M, Zhang RY, Wei HL, Li C, Shi Y, Zhang C, Wang YT, Wei D, Chen ZN, Bian H.   +14 more
europepmc   +3 more sources

The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery. [PDF]

Cells, 2023
Runsala M, Kuokkanen E, Uski E, Šuštar V, Balci MÖ, Rajala J, Paavola V, Mattila PK.   +7 more
europepmc   +3 more sources

Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases

Frontiers in Cell and Developmental Biology, 2021
Membrane trafficking is critical for cellular homeostasis, which is mainly carried out by small GTPases, a class of proteins functioning in vesicle budding, transport, tethering and fusion processes. The accurate and organized membrane trafficking relies
Zehui Lei, Zehui Lei, Jing Wang, Lingqiang Zhang, Cui Hua Liu, Cui Hua Liu   +5 more
doaj   +1 more source

Delta-Catenin as a Modulator of Rho GTPases in Neurons

Frontiers in Cellular Neuroscience, 2022
Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta, Maxsam S. Donta, Yogesh Srivastava, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +5 more
doaj   +1 more source

Small GTPase—A Key Role in Host Cell for Coronavirus Infection and a Potential Target for Coronavirus Vaccine Adjuvant Discovery

Viruses, 2022
Small GTPases are signaling molecules in regulating key cellular processes (e.g., cell differentiation, proliferation, and motility) as well as subcellular events (e.g., vesicle trafficking), making them key participants, especially in a great array of ...
Wei Hou, Sibei Wang, Heqiong Wu, Linli Xue, Bin Wang, Shouyu Wang, Haidong Wang   +6 more
doaj   +1 more source

The Small GTPase Arf6 Functions as a Membrane Tether in a Chemically-Defined Reconstitution System

Frontiers in Cell and Developmental Biology, 2021
Arf-family small GTPases are essential protein components for membrane trafficking in all eukaryotic endomembrane systems, particularly during the formation of membrane-bound, coat protein complex-coated transport carriers.
Kana Fujibayashi, Joji Mima
doaj   +1 more source