Results 1 to 10 of about 204,389 (300)
Detecting the Activation of Endogenous Small GTPases via Fluorescent Signals Utilizing a Split mNeonGreen: Small GTPase ActIvitY ANalyzing (SAIYAN) System [PDF]
Bio-ProtocolSmall GTPases function as molecular switches in cells, and their activation triggers diverse cellular responses depending on the GTPase type. Therefore, visualizing small GTPase activation in living cells is crucial because their activity is tightly ...
Miharu Maeda, Kota Saito
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The small GTPase MRAS is a broken switch [PDF]
Nature CommunicationsIntense research on founding members of the RAS superfamily has defined our understanding of these critical signalling proteins, leading to the premise that small GTPases function as molecular switches dependent on differential nucleotide loading.
Gabriela Bernal Astrain +5 more
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Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions [PDF]
Frontiers in Physiology, 2023 The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
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The small GTPase Rho5-Yet another player in yeast glucose signaling. [PDF]
PLoS GeneticsThe small GTPase Rho5 has been shown to be involved in regulating the Baker's yeast response to stress on the cell wall, high medium osmolarity, and reactive oxygen species.
Franziska Schweitzer +5 more
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Small GTPase ARL4C Associated with Various Cancers Affects Microtubule Nucleation [PDF]
BiomedicinesBackground/Objectives: The changes in the level of small GTPase ARL4C are associated with the initiation and progression of many different cancers. The content of ARL4C varies greatly between different tissues, and the induction of ARL4C expression leads
Evgeniia Ulas +2 more
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Methods for Controlling Small GTPase Activity. [PDF]
ChembiochemSmall GTPases comprise a diverse class of signaling proteins in mammalian cells and regulate a variety of cellular processes such as cell growth, cell movement, vesicle formation, and nuclear transport. Due to their involvement in critical cellular pathways, changes in the activation state of small GTPases due to genetic mutations or alterations in ...
Faulkner B, He Y, Sitrin D, Stains CI.
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WormBook, 2006 Small GTPases of the Ras superfamily are key regulators of diverse cellular and developmental events, including differentiation, cell division, vesicle transport, nuclear assembly, and control of the cytoskeleton. The C. elegans genome encodes 56 members of the major Ras GTPase subfamilies, including the Ras/Ral/Rap family, the Rho family, the Rab ...
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Frontiers in Cell and Developmental Biology, 2021 Membrane trafficking is critical for cellular homeostasis, which is mainly carried out by small GTPases, a class of proteins functioning in vesicle budding, transport, tethering and fusion processes. The accurate and organized membrane trafficking relies
Zehui Lei +5 more
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Delta-Catenin as a Modulator of Rho GTPases in Neurons
Frontiers in Cellular Neuroscience, 2022 Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta +5 more
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Viruses, 2022 Small GTPases are signaling molecules in regulating key cellular processes (e.g., cell differentiation, proliferation, and motility) as well as subcellular events (e.g., vesicle trafficking), making them key participants, especially in a great array of ...
Wei Hou +6 more
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