Results 91 to 100 of about 204,389 (300)

Small GTPases in Acrosomal Exocytosis

, 2015
Regulated exocytosis employs a conserved molecular machinery in all secretory cells. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Rab superfamilies are members of this machinery. Rab proteins are small GTPases that organize membrane microdomains on organelles by recruiting specific effectors that strongly influence ...
Bustos, Matias Alberto, Lucchesi, Ornella, Ruete, María Celeste, Mayorga, Luis Segundo, Tomes, Claudia Nora   +4 more
openaire   +3 more sources

Small GTPases in peroxisome dynamics

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
In this review article, we summarize current knowledge on peroxisome biogenesis/functions and the role that small GTPases may play in these processes. Precise intracellular distribution of cell organelles requires their regulated association to microtubules and the actin cytoskeleton.
Wilhelm W, Just, Johan, Peränen
openaire   +2 more sources

Isoprenoids, small GTPases and Alzheimer's disease [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
The mevalonate pathway is a crucial metabolic pathway for most eukaryotic cells. Cholesterol is a highly recognized product of this pathway but growing interest is being given to the synthesis and functions of isoprenoids. Isoprenoids are a complex class of biologically active lipids including for example, dolichol, ubiquinone, farnesylpyrophosphate ...
Gero P, Hooff, W Gibson, Wood, Walter E, Müller, Gunter P, Eckert   +3 more
openaire   +2 more sources

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Concerted Complex Assembly and GTPase Activation in the Chloroplast Signal Recognition Particle [PDF]

, 2011
The universally conserved signal recognition particle (SRP) and SRP receptor (SR) mediate the cotranslational targeting of proteins to cellular membranes.
Chandrasekar, Sowmya, Neher, Saskia, Nguyen, Thang X., Shan, Shu-ou, Walter, Peter   +4 more
core   +3 more sources

Small GTPases in platelet membrane trafficking [PDF]

Platelets, 2018
Our understanding of fundamental biological processes within platelets is continually evolving. A critical feature of platelet biology relates to the intricate uptake, packaging and release of bioactive cargo from storage vesicles, essential in mediating a range of classical (haemostasis/thrombosis) and non-classical (regeneration/inflammation ...
Tony G. Walsh, Yong Li, Andreas Wersäll, Alastair W. Poole   +3 more
openaire   +5 more sources

Harnessing Non‐Covalent Protein–Protein Interaction Domains for Production of Biocatalytic Materials Systems

Advanced Functional Materials, EarlyView.
Non‐covalent protein–protein interactions mediated by SH3, PDZ, or GBD domains enable the self‐assembly of stable and biocatalytically active hydrogel materials. These soft materials can be processed into monodisperse foams that, once dried, exhibit enhanced mechanical stability and activity and are easily integrated into microstructured flow ...
Julian S. Hertel, Maria Alessandra Martini, Marius Stoeckle, Annika J. Weber, Kersten S. Rabe, Christof M. Niemeyer   +5 more
wiley   +1 more source

Small GTPase Rab3B: biological properties and possible role in carcinogenesis

Успехи молекулярной онкологии, 2019
Proteins of the superfamily of small guanosine triphosphate hydrolase (GTPase) perform various functions: from the control of cell proliferation to the regulation of vesicular transport. The superfamily of small GTPase Ras includes more than 150 proteins,
A. A. Budko, P. A. Khesina, L. M. Diakov, N. L. Lazarevich   +3 more
doaj   +1 more source

Crystallization of YIoQ, a GTPase of unknown function essential for Bacillus subtilis viability [PDF]

, 2004
YLoQ is a putative ATP/GTP-binding protein of unknown function identified from the complete sequence of the Bacillus subtilis genome. A gene-knockout programme established that yloQ is one of a set of some 270 indispensable genes for the viability of ...
Blagova, E, Brannigan, J A, Cladiere, L, Levdikov, V M, Seror, S J, Wilkinson, A J   +5 more
core   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source