Results 91 to 100 of about 192,224 (247)

Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]

, 1993
The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico, Goody, R. S., John, J., Rensland, H., Schlichting, I., Vetter, I., Wittinghofer, A.   +6 more
core  

In vivo monitoring of plant small GTPase activation using a Förster resonance energy transfer biosensor

Plant Methods, 2018
Background Small GTPases act as molecular switches that regulate various plant responses such as disease resistance, pollen tube growth, root hair development, cell wall patterning and hormone responses.
Hann Ling Wong, Akira Akamatsu, Qiong Wang, Masayuki Higuchi, Tomonori Matsuda, Jun Okuda, Ken-ichi Kosami, Noriko Inada, Tsutomu Kawasaki, Takako Kaneko-Kawano, Shingo Nagawa, Li Tan, Yoji Kawano, Ko Shimamoto   +13 more
doaj   +1 more source

Crystallization of YIoQ, a GTPase of unknown function essential for Bacillus subtilis viability [PDF]

, 2004
YLoQ is a putative ATP/GTP-binding protein of unknown function identified from the complete sequence of the Bacillus subtilis genome. A gene-knockout programme established that yloQ is one of a set of some 270 indispensable genes for the viability of ...
Blagova, E, Brannigan, J A, Cladiere, L, Levdikov, V M, Seror, S J, Wilkinson, A J   +5 more
core   +1 more source

CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis [PDF]

, 2020
Jisoo S. Han, Keiko Hino, Wenzhe Li, Raenier V. Reyes, César P. Canales, Adam M. Miltner, Yasmin Haddadi, Junqing Sun, Chao-Yin Chen, Anna La Torre, Sergi Simó   +10 more
openalex   +1 more source

Roles of Rap1 signaling in tumor cell migration and invasion

Cancer Biology & Medicine, 2017
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization.
Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring, Li Su   +4 more
doaj   +1 more source

Molecular mechanisms of Sar/Arf GTPases in vesicular trafficking in yeast and plants

Frontiers in Plant Science, 2014
Small GTPase proteins play essential roles in the regulation of vesicular trafficking systems in eukaryotic cells. Two types of small GTPases, secretion-associated Ras-related protein (Sar) and ADP-ribosylation factor (Arf), act in the biogenesis of ...
Tomohiro eYorimitsu, Ken eSato, Masaki eTakeuchi   +2 more
doaj   +1 more source

Chronic exposure to simulated space conditions predominantly affects cytoskeleton remodeling and oxidative stress response in mouse fetal fibroblasts [PDF]

, 2014
Microgravity and cosmic rays as found in space are difficult to recreate on earth. However, ground-based models exist to simulate space flight experiments.
Abou-El-Ardat, Khalil, Baatout, Sarah, Beck, Michaël, De Vos, Winnok, El-Saghire, Hussein, Janssen, Ann, Michaux, Arlette, Moreels, Marjan, Neefs, Mieke, Quintens, Roel, Tabury, Kevin, Van Oostveldt, Patric   +11 more
core   +2 more sources

Functional implications of Rab27 GTPases in Cancer

Cell Communication and Signaling, 2018
Background The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in ...
Zhihong Li, Rui Fang, Jia Fang, Shasha He, Tang Liu   +4 more
doaj   +1 more source

Role of βPix in the kidney

Frontiers in Physiology, 2012
Small GTPases function as molecular switches in cell signaling, alternating between an inactive, GDP-bound state, and active GTP-bound state. βPix is one of guanine nucleotide exchange factors (GEFs) that catalyze the exchange of bound GDP for ambient ...
Alexander eStaruschenko, Andrey eSorokin
doaj   +1 more source

IAPs as E3 ligases of Rac1 : shaping the move [PDF]

, 2012
Inhibitors of Apoptosis Proteins (IAPs) are well-studied E3 ubiquitin ligases predominantly known for regulation of apoptosis. We uncovered that IAPs can function as a direct E3 ubiquitin ligase of RhoGTPase Rac1.
Oberoi-Khanuja, Tripat Kaur, Rajalingam, Krishnaraj   +1 more
core   +1 more source