Results 101 to 110 of about 192,224 (247)

Intensiometric biosensors visualize the activity of multiple small GTPases in vivo

Nature Communications, 2019
FRET sensors hardly achieve visualization of spatiotemporal dynamics of protein activity in vivo. Here the authors present intensiometric small GTPase biosensors based on dimerization-dependent fluorescent proteins that enable monitoring of activity of ...
Jihoon Kim, Sangkyu Lee, Kanghoon Jung, Won Chan Oh, Nury Kim, Seungkyu Son, YoungJu Jo, Hyung-Bae Kwon, Won Do Heo   +8 more
doaj   +1 more source

Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae. [PDF]

, 2019
The evolutionarily conserved Target of Rapamycin (TOR) complex-2 (TORC2) is an essential regulator of plasma membrane homeostasis in budding yeast (Saccharomyces cerevisiae).
Locke, Melissa N, Thorner, Jeremy
core   +1 more source

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells [PDF]

, 2014
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity,
Alonso, Daniel Fernando, Cardama, Georgina Alexandra, Ciarlantini, Matias Sebastián, Comin, Maria Julieta, Gandolfi Donadío, Lucía, Gomez, Daniel Eduardo, González, Nazareno, Lorenzano Menna, Pablo   +7 more
core   +2 more sources

Conformational control of small GTPases by AMPylation [PDF]

, 2020
Katja Barthelmes, Evelyn Ramcke, Hyun-Seo Kang, Michael Sattler, Aymelt Itzen   +4 more
openalex   +1 more source

The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth

Biology Open, 2015
The generation of neuronal morphology requires transport vesicles originating from the Golgi apparatus (GA) to deliver specialized components to the axon and dendrites.
Leo Chang, Tabita Kreko-Pierce, Benjamin A. Eaton   +2 more
doaj   +1 more source

Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish [PDF]

, 2017
The authors would like to thank the Royal Society of London, the National Eye Research Centre, the Visual Research Trust, Fight for Sight, the W.H. Ross Foundation, the Rosetrees Trust, and the Glasgow Children’s Hospital Charity for supporting this work.
A Eblimit, A Hameed, AF Wright, AI Hollander den, B Kennedy, BW Draper, C Insinna, C Turney, CA Murga-Zamalloa, CM Louie, CS Mellersh, D Deretic, D Mustafi, DH Hong, EM Morrow, F Liu, G Stearns, G Ying, H Patil, H Wang, HH Arts, J Kim, J Wang, J Won, JC Booij, JE Westfall, JM Corless, JP Boylan, KL Cerveny, KL Coene, L Sang, MM Humphries, MV Nachury, O Rinner, OL Moritz, P Castagnet, PD Alfinito, PH Balm, R Bachmann-Gagescu, R Roepman, R Roepman, S Gerber, SC Neuhauss, SE Brockerhoff, SR Patnaik, TA Mavlyutov, TP Dryja, V Traverso, VS Lopes, X Shu, X Shu, X Shu., Y Wada., Y Zhao, YV Makhankov   +54 more
core   +4 more sources

TAS1R3 influences GTPase-dependent signaling in human islet β-cells

Frontiers in Endocrinology
BackgroundThe taste receptor type 1 member 3 (TAS1R3), a G protein-coupled receptor (GPCR), is expressed in pancreatic islet β-cells where it may influence intracellular signaling pathways critical for β-cell function.
Rajakrishnan Veluthakal, Miwon Ahn, Eunjin Oh, Debbie C. Thurmond   +3 more
doaj   +1 more source

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. [PDF]

, 2017
Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease.
Aplin, Andrew E., Benovic, Jeffrey L., Chua, Vivian, Lapadula, Dominic, Randolph, Clinita, Wedegaertner, Philip B.   +5 more
core   +1 more source

An Arabidopsis GRIP domain protein locates to the trans‐Golgi and binds the small GTPase ARL1 [PDF]

, 2005
Maita Latijnhouwers, Chris Hawes, Claudine M. Carvalho, Karl Oparka, Alison K. Gillingham, Petra C. Boevink   +5 more
openalex   +1 more source

The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases

, 2021
Stefano Barbera, Roberta Lugano, Alessia Pedalina, Maurizio Mongiat, Annalisa Santucci, Gian Marco Tosi, Anna Dimberg, Federico Galvagni, Maurizio Orlandini   +8 more
openalex   +2 more sources