Multiple Roles of the Small GTPase Rab7
Cells, 2016 Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied.
Flora Guerra, Cecilia Bucci
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Small GTPase patterning: How to stabilise cluster coexistence.
PLoS ONE, 2019 Many biological processes have to occur at specific locations on the cell membrane. These locations are often specified by the localised activity of small GTPase proteins.
Bas Jacobs, Jaap Molenaar, Eva E Deinum
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The small GTPase Sar1, control centre of COPII trafficking
FEBS Letters, 2023 Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates with the endoplasmic reticulum (ER) membrane and recruits COPII components, orchestrating cargo concentration and membrane deformation.
Sander Van der Verren, Giulia Zanetti
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BRAG1/IQSEC2 as a regulator of small GTPase-dependent trafficking [PDF]
Small GTPases, 2018 Amber Petersen +2 more
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ER membrane contact sites support endosomal small GTPase conversion for exosome secretion
Journal of Cell Biology, 2022 Exosomes are derived from endosomal compartments with an ill-defined molecular identity and whose trafficking steps to secretion are poorly understood.
F. Verweij +10 more
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Targeting the Small GTPase Superfamily through Their Regulatory Proteins
Angewandte Chemie, 2020 The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches essential for numerous cellular processes. Mutations or dysregulation of these proteins are associated with many diseases, but unsuccessful attempts to target the small ...
J. Gray, F. Delft, P. Brennan
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The Small GTPase Superfamily in Plants: A Conserved Regulatory Module with Novel Functions.
Annual Review of Plant Biology, 2020 Small GTP-binding proteins represent a highly conserved signaling module in eukaryotes that regulates diverse cellular processes such as signal transduction, cytoskeletal organization and cell polarity, cell proliferation and differentiation ...
E. Nielsen
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Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells
Frontiers in Cell and Developmental Biology, 2022 Membrane polarity, defined as the asymmetric distribution of lipids and proteins in the plasma membrane, is a critical prerequisite for the development of multicellular tissues, such as epithelia and endothelia.
Klaus Ebnet +5 more
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An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways
Nature Methods, 2005 Takanari Inoue, Won Do Heo, Tobias Meyer
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Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. [PDF]
PLoS Computational Biology, 2006 Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster ...
Andrew B Goryachev, Alexandra V Pokhilko
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