Results 11 to 20 of about 319,680 (268)
The small GTPase MRAS is a broken switch [PDF]
Nature CommunicationsIntense research on founding members of the RAS superfamily has defined our understanding of these critical signalling proteins, leading to the premise that small GTPases function as molecular switches dependent on differential nucleotide loading.
Gabriela Bernal Astrain +5 more
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Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions [PDF]
Frontiers in Physiology, 2023 The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
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Small GTPase ARL4C Associated with Various Cancers Affects Microtubule Nucleation [PDF]
BiomedicinesBackground/Objectives: The changes in the level of small GTPase ARL4C are associated with the initiation and progression of many different cancers. The content of ARL4C varies greatly between different tissues, and the induction of ARL4C expression leads
Evgeniia Ulas +2 more
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The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing [PDF]
Frontiers in Cell and Developmental Biology, 2022 The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated human genes, the family has a broad expression throughout cells of the body. Members of the family have multiple exons that require splicing.
Akansha S. Das +24 more
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Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. [PDF]
PLoS Computational Biology, 2006 Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster ...
Andrew B Goryachev, Alexandra V Pokhilko
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Multiple Roles of the Small GTPase Rab7
Cells, 2016 Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied.
Flora Guerra, Cecilia Bucci
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A highly-sensitive high throughput assay for dynamin's basal GTPase activity. [PDF]
PLoS ONE, 2017 Clathrin-mediated endocytosis is the major pathway by which cells internalize materials from the external environment. Dynamin, a large multidomain GTPase, is a key regulator of clathrin-mediated endocytosis.
Aparna Mohanakrishnan +5 more
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The small GTPase Rif is dispensable for platelet filopodia generation in mice. [PDF]
PLoS ONE, 2013 Formation of filopodia and other shape change events are vital for platelet hemostatic function. The mechanisms regulating filopodia formation by platelets are incompletely understood however.
Robert Goggs +3 more
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Small GTPase Ran and Ran-binding proteins
Biomolecular Concepts, 2012 Like many other small GTPases, Ran functions in eukaryotic cells as a molecular switch that cycles between GTP- and GDP-bound forms. Through the proper modulation of the GTP/GDP cycle, Ran functions with a number of Ran-binding proteins to control a ...
Nagai Masahiro, Yoneda Yoshihiro
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mBio, 2020 Legionella pneumophila governs its interactions with host cells by secreting >300 different “effector” proteins. Some of these effectors contain eukaryotic domains such as the RCC1 (regulator of chromosome condensation 1) repeats promoting the activation
A. Leoni Swart +11 more
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