Results 211 to 220 of about 204,389 (300)

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety. [PDF]

Sci Adv
Pan HQ, Liu WZ, Yang CZ, Jiang SY, Zhang MX, Hu P, Yang HT, Wang YY, Li YQ, Tu JL, Chen WB, Liu L, Pan BX, Zhang WH.   +13 more
europepmc   +1 more source

Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus. [PDF]

Front Mol Biosci, 2023
Czigleczki J, de Resende Lara PT, Dudas B, Jang H, Perahia D, Nussinov R, Balog E.   +6 more
europepmc   +1 more source

The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism. [PDF]

Mol Metab
Kaneko K, Lu W, Xu Y, Morozov A, Fukuda M.   +4 more
europepmc   +1 more source

Standardized Parts for Activation of Small GTPase Signaling in Living Cells. [PDF]

Angew Chem Int Ed Engl
He Y, Faulkner BM, Roberti MA, Bassford DK, Stains CI.   +4 more
europepmc   +1 more source

Protocadherin-7 Regulates Monocyte Migration Through Regulation of Small GTPase RhoA and Rac1. [PDF]

Int J Mol Sci
Kim H, Takegahara N, Choi Y.
europepmc   +1 more source

In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia. [PDF]

J Genet Eng Biotechnol
Jasni N, Abd Halim KB, Kin WW, Lau D, Young C, Hoffmann P, Othman N.   +6 more
europepmc   +1 more source

Molecular crosstalk via exosomes in lung cancer progression

Interdisciplinary Medicine, EarlyView.
“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan   +3 more
wiley   +1 more source

Integrated Analysis of the Anoikis-Related Signature Identifies Rac Family Small GTPase 3 as a Novel Tumor-Promoter Gene in Hepatocellular Carcinoma. [PDF]

MedComm (2020)
Wu D, Liu ZK, Sun Y, Gou CH, Shang RZ, Lu M, Zhang RY, Wei HL, Li C, Shi Y, Zhang C, Wang YT, Wei D, Chen ZN, Bian H.   +14 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source