Results 231 to 240 of about 7,610,404 (354)

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Editorial: Energy Requirements in Membrane Trafficking

Frontiers in Cell and Developmental Biology, 2021
Carlos M. Guardia, Aitor Hierro, Aitor Hierro, David C. Gershlick   +3 more
doaj   +1 more source

GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR

Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen   +8 more
openalex   +1 more source

CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth

, 2013
T. Y. Kim, S. Jackson, Y. Xiong, T. G. Whitsett, J. R. Lobello, G. J. Weiss, N. L. Tran, Y.-J. Bang, C. J. Der   +8 more
openalex   +2 more sources

Coupling spindle position with mitotic exit in budding yeast: The multifaceted role of the small GTPase Tem1 [PDF]

, 2015
Ilaria Scarfone, Simonetta Piatti
openalex   +1 more source

Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation

The FASEB Journal, 2017
S. Kakuta, Junji Yamaguchi, Chigure Suzuki, M. Sasaki, S. Kazuno, Y. Uchiyama   +5 more
semanticscholar   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, EarlyView.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

Upregulated small GTPase immunity-associated proteins confer resistance to <i>Neospora caninum</i> in rat and bovine cells. [PDF]

Front Cell Infect Microbiol
Azam AR, Mia MM, Bedwani J, Witola WH.
europepmc   +1 more source

Cell aggregation activates small GTPase Rac1 and induces CD44 cleavage by maintaining lipid raft integrity. [PDF]

J Biol Chem, 2023
Li D, Park Y, Hemati H, Liu X.
europepmc   +1 more source

The TBC/RabGAP Armus regulates autophagy via a cross-talk between the small GTPases Rac1 and Rab7

, 2019
Bernadette Carroll
openalex   +1 more source