Results 21 to 30 of about 192,224 (247)

The small GTPase ARF6 regulates GABAergic synapse development

Molecular Brain, 2020
ADP ribosylation factors (ARFs) are a family of small GTPases composed of six members (ARF1–6) that control various cellular functions, including membrane trafficking and actin cytoskeletal rearrangement, in eukaryotic cells.
Hyeonho Kim, Hyeji Jung, Hyunsu Jung, Seok-Kyu Kwon, Jaewon Ko, Ji Won Um   +5 more
doaj   +1 more source

Regulation of polarised growth in fungi [PDF]

, 2008
Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo, Adamo, Adams, Akashi, Ayad-Durieux, Bachewich, Bartnicki-Garcia, Bartnicki-Garcia, Bassilana, Bassilana, Bassilana, Behrens, Berman, Bidlingmaier, Bose, Boyce, Boyce, Boyce, Boyd, Brown, Caviston, Chant, Chapa y Lazo, Collinge, Colman-Lerner, Court, Crampin, Cvrckova, Dong, Drgonova, Dunkler, Feng, Finger, France, Gao, Girbardt, Gladfelter, Goehring, Gorovits, Gulli, Guo, Harris, Harris, Hartwell, Hergovich, Hou, Hou, Irazoqui, Jin, Karnoub, Knechtle, Kohno, Konzack, Kron, Leberer, Leberer, Leberer, Leonhard, Lew, Li, Liu, Loeb, Loeb, Longtine, Mahlert, Mata, McCollum, McCusker, Medkova, Mehta, Mendenhall, Nelson, Nonaka, Novick, Pan, Park, Pearson, Peter, Peter E. Sudbery, Philippsen, Punt, Qadota, Racki, Read, Santangelo, Schmidt, Seiler, Seiler, Sinha, Smith, Soll, Stevenson, Sudbery, Sudbery, Sudbery, Tamaskovic, Tanaka, Tcheperegine, Trinci, Verde, Versele, Virag, Virag, Walton, Walworth, Wedlich-Soldner, Wedlich-Soldner, Wendland, Wu, Yarden, Zhang, Zheng, Zheng   +112 more
core   +1 more source

Small GTPases and cilia [PDF]

Protein & Cell, 2011
Small GTPases are key molecular switches that bind and hydrolyze GTP in diverse membrane- and cytoskeleton-related cellular processes. Recently, mounting evidences have highlighted the role of various small GTPases, including the members in Arf/Arl, Rab, and Ran subfamilies, in cilia formation and function.
Yujie, Li, Jinghua, Hu
openaire   +2 more sources

Multiple Roles of the Small GTPase Rab7

Cells, 2016
Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied.
Flora Guerra, Cecilia Bucci
doaj   +1 more source

A non-linear system patterns Rab5 GTPase on the membrane

eLife, 2020
Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors ...
Alice Cezanne, Janelle Lauer, Anastasia Solomatina, Ivo F Sbalzarini, Marino Zerial   +4 more
doaj   +1 more source

A highly-sensitive high throughput assay for dynamin's basal GTPase activity. [PDF]

PLoS ONE, 2017
Clathrin-mediated endocytosis is the major pathway by which cells internalize materials from the external environment. Dynamin, a large multidomain GTPase, is a key regulator of clathrin-mediated endocytosis.
Aparna Mohanakrishnan, Triet Vincent M Tran, Meera Kumar, Hong Chen, Bruce A Posner, Sandra L Schmid   +5 more
doaj   +1 more source

Role of Small GTPase RhoA in DNA Damage Response

Biomolecules, 2021
Accumulating evidence has suggested a role of the small GTPase Ras homolog gene family member A (RhoA) in DNA damage response (DDR) in addition to its traditional function of regulating cell morphology.
Chibin Cheng, Daniel Seen, Chunwen Zheng, Ruijie Zeng, Enmin Li   +4 more
doaj   +1 more source

Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]

, 2017
[FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura, Bortolus, Marco, Carbonera, Donatella, Costantini, Paola, DE FILIPPIS, Vincenzo, DE ROSA, Edith, Doni, Davide, Galazzo, Laura, Maso, Lorenzo   +8 more
core   +1 more source

Small GTPase Ran and Ran-binding proteins

Biomolecular Concepts, 2012
Like many other small GTPases, Ran functions in eukaryotic cells as a molecular switch that cycles between GTP- and GDP-bound forms. Through the proper modulation of the GTP/GDP cycle, Ran functions with a number of Ran-binding proteins to control a ...
Nagai Masahiro, Yoneda Yoshihiro
doaj   +1 more source

The small GTPase Rif is dispensable for platelet filopodia generation in mice. [PDF]

PLoS ONE, 2013
Formation of filopodia and other shape change events are vital for platelet hemostatic function. The mechanisms regulating filopodia formation by platelets are incompletely understood however.
Robert Goggs, Joshua S Savage, Harry Mellor, Alastair W Poole   +3 more
doaj   +1 more source