Results 21 to 30 of about 319,680 (268)
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. [PDF]
PLoS ONE, 2010 Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Here, we show that the rho guanine ...
Karina Haebig +8 more
doaj +1 more source
Spots, strips, and spiral waves in models for static and motile cells [PDF]
J. Math. Biol. 82, 28 (2021), 2019 The polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases. The activity of GTPases causes assembly of filamentous actin (by GTPases Cdc42, Rac), resulting in protrusion of the cell edge.
arxiv +1 more source
Critical appraisal on mitochondrial dysfunction in Alzheimer’s disease
AGING MEDICINE, Volume 5, Issue 4, Page 272-280, December 2022., 2022 Amyloid plaques deposit on neurons in case of Alzheimer's Disease. Mitochondria play a vital role in pathogenesis of Alzheimer's Disease. Mitochondrial dysfunction can lead to formation of mPTP, alteration of complexes 1,3 and 4, deficits in bioenergetics with impaired mitochondrial biogenesis. Abstract It is widely recognized that Alzheimer's disease (
Faizan Ahmad, Punya Sachdeva
wiley +1 more source
The small GTPase RhoG mediates glioblastoma cell invasion
Molecular Cancer, 2012 Background The invasion of glioblastoma cells into regions of the normal brain is a critical factor that limits current therapies for malignant astrocytomas.
Kwiatkowska Aneta +10 more
doaj +1 more source
The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication. [PDF]
PLoS Pathogens, 2009 The intracellular pathogen Brucella abortus survives and replicates inside host cells within an endoplasmic reticulum (ER)-derived replicative organelle named the "Brucella-containing vacuole" (BCV).
Emilie Fugier +7 more
doaj +1 more source
Frontiers in Marine Science, 2023 The Ras superfamily of small guanosine triphosphatases (GTPases) are a large group of small GTP-binding proteins, which play crucial roles in basic cellular processes in all eukaryotes. In this study, by analyzing the gene structure, temporal and spatial
Shuqing Si +18 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Membrane tethering is a crucial step to determine the spatiotemporal specificity of secretory and endocytic trafficking pathways in all eukaryotic endomembrane systems.
Sanae Ueda, Naoki Tamura, Joji Mima
doaj +1 more source
The small GTPase RhoB regulates TNFα signaling in endothelial cells. [PDF]
PLoS ONE, 2013 The inflammatory response of endothelial cells triggered by cytokines such as TNFα and IL1β plays a pivotal role in innate immunity. Upon pro-inflammatory cytokine stimulation, endothelial cells produce chemokines and cytokines that attract and activate ...
Jeffrey Kroon +4 more
doaj +1 more source
The molecular genetics of RASopathies: An update on novel disease genes and new disorders
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 425-439, December 2022., 2022 Abstract Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK) cascade underlies the RASopathies, a family of clinically related disorders affecting development and growth. In RASopathies, increased RAS‐MAPK signaling can result from the upregulated activity of various RAS GTPases, enhanced function of proteins positively ...
Marco Tartaglia +2 more
wiley +1 more source
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Nature Communications, 2016 Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia +13 more
doaj +1 more source