The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]
, 2013 Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts +79 more
core +2 more sources
The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling
Journal of Cell Science, 2020 Epithelial cells, such as liver-resident hepatocytes, rely heavily on the Rab family of small GTPases to perform membrane trafficking events that dictate cell physiology and metabolism. Not surprisingly, disruption of several Rab proteins can manifest in
Kristina Drizyte-Miller +4 more
semanticscholar +1 more source
The small GTPase ARF6 regulates GABAergic synapse development
Molecular Brain, 2020 ADP ribosylation factors (ARFs) are a family of small GTPases composed of six members (ARF1–6) that control various cellular functions, including membrane trafficking and actin cytoskeletal rearrangement, in eukaryotic cells.
Hyeonho Kim +5 more
doaj +1 more source
A non-linear system patterns Rab5 GTPase on the membrane
eLife, 2020 Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors ...
Alice Cezanne +4 more
doaj +1 more source
Role of Small GTPase RhoA in DNA Damage Response
Biomolecules, 2021 Accumulating evidence has suggested a role of the small GTPase Ras homolog gene family member A (RhoA) in DNA damage response (DDR) in addition to its traditional function of regulating cell morphology.
Chibin Cheng +4 more
doaj +1 more source
Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]
, 2017 [FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura +8 more
core +1 more source
A highly-sensitive high throughput assay for dynamin's basal GTPase activity. [PDF]
PLoS ONE, 2017 Clathrin-mediated endocytosis is the major pathway by which cells internalize materials from the external environment. Dynamin, a large multidomain GTPase, is a key regulator of clathrin-mediated endocytosis.
Aparna Mohanakrishnan +5 more
doaj +1 more source
The small GTPase Rif is dispensable for platelet filopodia generation in mice. [PDF]
PLoS ONE, 2013 Formation of filopodia and other shape change events are vital for platelet hemostatic function. The mechanisms regulating filopodia formation by platelets are incompletely understood however.
Robert Goggs +3 more
doaj +1 more source
Structure and function of bacterial dynamin-like proteins [PDF]
, 2012 Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core +1 more source
Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42
Journal of Biological Chemistry, 2018 Inflammation is a major driver of tumor progression and metastasis, although the mechanisms by which proinflammatory cytokines drive metastatic invasion are unknown.
G. Razidlo, Kevin M Burton, M. McNiven
semanticscholar +1 more source