Results 41 to 50 of about 192,224 (247)
The small GTPase RhoG mediates glioblastoma cell invasion
Molecular Cancer, 2012 Background The invasion of glioblastoma cells into regions of the normal brain is a critical factor that limits current therapies for malignant astrocytomas.
Kwiatkowska Aneta +10 more
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Structure and function of bacterial dynamin-like proteins [PDF]
, 2012 Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core +1 more source
Frontiers in Cell and Developmental Biology, 2020 Membrane tethering is a crucial step to determine the spatiotemporal specificity of secretory and endocytic trafficking pathways in all eukaryotic endomembrane systems.
Sanae Ueda, Naoki Tamura, Joji Mima
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Dual positive and negative regulation of GPCR signaling by GTP hydrolysis [PDF]
, 2009 G protein-coupled receptors (GPCRs) regulate a variety of intracellular pathways through their ability to promote the binding of GTP to heterotrimeric G proteins. Regulator of G protein signaling (RGS) proteins increase the intrinsic GTPase activity of G-
Berg, Hugo van den +8 more
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Small GTPase proteins in macroautophagy [PDF]
Small GTPases, 2016 Macroautophagy, a highly conserved process in eukaryotic cells, is initiated in response to stress, especially nutrient starvation. Macroautophagy helps cells survive by engulfing proteins and organelles into an unusual double-membraned structure called the autophagosome, which then fuses with the lysosome.
Shu Yang, Anne Rosenwald
openaire +2 more sources
The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication. [PDF]
PLoS Pathogens, 2009 The intracellular pathogen Brucella abortus survives and replicates inside host cells within an endoplasmic reticulum (ER)-derived replicative organelle named the "Brucella-containing vacuole" (BCV).
Emilie Fugier +7 more
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Frontiers in Cell and Developmental Biology, 2022 The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated human genes, the family has a broad expression throughout cells of the body. Members of the family have multiple exons that require splicing.
Akansha S. Das +24 more
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Endocytic signaling in leaves and roots: same rules different players. [PDF]
, 2012 To take up proteins and other components required by the cell, cells internalize a portion of the plasma membrane (PM), which invaginates to form a closed vesicle within the cytoplasm in a process known as endocytosis. The major plant endocytic mechanism
Craddock, Christian, Yang, Zhenbiao
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Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Nature Communications, 2016 Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia +13 more
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The gateway to chloroplast: re-defining the function of chloroplast receptor proteins [PDF]
, 2012 Chloroplast biogenesis often requires a tight orchestration between gene expression (both plastidial and nuclear) and translocation of similar to 3000 nuclear-encoded proteins into the organelle.
Bölter, Bettina +2 more
core +1 more source