Nature Communications, 2016 Bicyclic peptides are promising scaffolds for the development of inhibitors of biological targets that proved intractable by typical small molecules.
Philipp M. Cromm +5 more
semanticscholar +1 more source
Turing instabilities in a mathematical model for signaling networks
, 2011 GTPase molecules are important regulators in cells that continuously run through an activation/deactivation and membrane-attachment/membrane-detachment cycle. Activated GTPase is able to localize in parts of the membranes and to induce cell polarity.
AB Goryachev +27 more
core +1 more source
Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. [PDF]
, 2015 The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology (PH) domain. As the first phosphoinositide binding module domain to be discovered, the PH domain recruits diverse protein architectures to cellular ...
Abagyan, Ruben +3 more
core +3 more sources
MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus
Nature Communications, 2019 In Myxococcus xanthus, directed movement is controlled by pole-to-pole oscillations of the small GTPase MglA and its GAP MglB. Here authors report the complete MglA/MglB structural cycle and uncover that MglA is a three-state GTPase that adopts an ...
Christian Galicia +8 more
doaj +1 more source
The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport
eLife, 2014 The construction of cilia and flagella depends on intraflagellar transport (IFT), the bidirectional movement of two protein complexes (IFT-A and IFT-B) driven by specific kinesin and dynein motors.
Diego Huet +3 more
doaj +1 more source
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development [PDF]
, 2003 Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown.
Chan, David C. +5 more
core +2 more sources
The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms [PDF]
, 2008 © 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Ammerer G. +58 more
core +3 more sources
Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges
Cells, 2019 Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle between an inactive state when bound to GDP and an active state when associated to GTP.
Néstor Prieto‐Domínguez +2 more
semanticscholar +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA
Molecular Biology of the Cell, 2017 Different forms of nuclear envelope–spanning LINC complexes have opposing roles in the transcription-independent control of the small GTPase RhoA. Competition between LINC complexes in the nuclear envelope may therefore dictate the outcome of signaling ...
Ketan Thakar +3 more
semanticscholar +1 more source