Results 91 to 100 of about 720,845 (293)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

Journal of Pharmacological Sciences, 2017
Peroxisome proliferator-activated receptor α (PPARα) is a well-known therapeutic target for treating hyperlipidemia. K-877 is a novel selective PPARα modulator (SPPARMα) that enhances PPARα transcriptional activity with high selectivity and potency ...
Kenta Takei, Yoshimi Nakagawa, Yunong Wang, Song-iee Han, Aoi Satoh, Motohiro Sekiya, Takashi Matsuzaka, Hitoshi Shimano   +7 more
doaj   +1 more source

Brush border digestion : development of a physiologically relevant in vitro model : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Physiology at Massey University, Manawatū, New Zealand [PDF]

, 2018
Chapter Two has, in part, been published in the Springer publication, Reviews of Physiology, Biochemistry and Pharmacology, but the Author retains the right to publish the material in any collection consisting of the Author's own works: Hooton, D ...
Hooton, Diane Frances
core  

Herbal extracts modulate the amplitude and frequency of slow waves in circular smooth muscle of mouse small intestine [PDF]

, 2004
Background: Herbal preparations like STW 5 (Iberogast(R)) are widely used drugs in the treatment of dyspepsia and motility-related disorders of the gastrointestinal tract.
Allescher, H. D., Göke, B., Kelber, O., Schirra, J., Sibaev, A., Storr, Martin, Weiser, D.   +6 more
core   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

The influence of intestine-based treatment using Xuan Bai Cheng Qi Tang on the concentration of trace elements in the main organs of COPD rats

Journal of Traditional Chinese Medical Sciences, 2017
Objective: To test two theories from traditional Chinese medicine: “exterior–interior relationship between the lung and large intestine” and “treating from the intestine principle for lung disorders”. The influence of intestine-based treatment using Xuan
Jiamin Yang, Yan Sun, Jinghong Hu, Xianggen Zhong, Fengjie Zheng, Min Wang, Yanan Wei, Jinchao Zhang, Yuhang Li   +8 more
doaj   +1 more source

Expression Analysis of Interleukin-13 Gene in the Small Intestine of Three Genotypes of chickens Administered Conventional Antibiotics and Garlic

, 2023
Okenyi Nj, Ndofor-Foleng Hm, Tchoupou-Tchoupou Ec, Nnanna Ephraim Ikeh, Nwenya Jm, Amaefule Bc, Uberu Cpn, Nwosu Ic, Onyimonyi Ae, B Abdellatif, C Mcveigh, G Bendriss, A Chaari, J Ansary, T Forbes-Hernndez, E Gil, D Cianciosi, J Zhang, M Elexpuru-Zabaleta, J Simal-Gandara, F Giampieri, M Battino, Y Attia, M Rahman, M Hossain, S Basiouni, A Khafaga, A Shehata, H Hafez, R Bailey, H Cheng, M Chase-Topping, J Mays, O Anacleto, J Dunn, A Doeschl-Wilson, A Elbaz, N Ibrahim, A Shehata, N Mohamed, Abdel-Moneim Am, A Elbaz, E Ashmawy, A Salama, Abdel Moneim, Ame Badri, F Thabet, H, K Felisbino, J Granzotti, L Bello-Santos, Guiloski Ic, S Fulla, R Goel, S Apostolidis, M Painter, D Mathew, A Pattekar, O Kuthuru, E Wherry, L Horev-Azaria, E Shlomit, Nira Iv, P Sarah, M David, Talia, Aharon Rabinkov, Meir, Jasmine, Ninette Naphtali, S, O Iyasere, O Ajayi, S Alade, V Akinbode, K Livak, Schmittgen Td, S Maggini, Pierre Calder, P, I Malgwi, V Halas, P Grnvald, S Schiavon, I Jcsk, S Mandal, A Das, S Dey, U Sahoo, S Bose, A Bose, M Ramadan, C Mckenzie, J Tan, L Macia, C Mackay, H Ndofor-Foleng, V Oleforuh-Okoleh, G Musongong, J Ohageni   +99 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Clinico-pathological spectrum of small intestinal lesions at a tertiary care hospital [PDF]

Al Ameen Journal of Medical Sciences, 2020
Background: Small intestine is affected by various diseases ranging from developmental abnormalities, inflammatory diseases, malignancies etc. This study was carried out to study the occurrence and evaluate histopathology of small intestinal lesions and ...
M.H. Prabhu Mural, N.V. Kalyan, Mallikarjun A. Pattanashetti, Shivakumar S. Inamdar   +3 more
doaj  

The digestion of yeast cell wall polysaccharides in veal calves [PDF]

, 1976
1. The digestibility of the cell wall polysaccharides of an alkane-grown yeast in different parts of the digestive tract of two veal calves fitted with re-entrant cannulas at the end of the ileum was studied by replacing part of the skim-milk powder of ...
Gaillard, B.D.E., Weerden, E.J., van
core   +2 more sources