Results 71 to 80 of about 429,180 (269)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sonography of the small intestine

World Journal of Gastroenterology, 2009
In the last two decades, there has been substantial development in the diagnostic possibilities for examining the small intestine. Compared with computerized tomography, magnetic resonance imaging, capsule endoscopy and double-balloon endoscopy, ultrasonography has the advantage of being cheap, portable, flexible and user- and patient-friendly, while ...
Kim, Nylund, Svein, Ødegaard, Trygve, Hausken, Geir, Folvik, Gülen Arslan, Lied, Ivan, Viola, Helwig, Hauser, Odd-Helge, Gilja   +7 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Effect of experimental ileitis on expression of tlr-2 in lymphfocytes of small intestine

Zaporožskij Medicinskij Žurnal, 2013
Introduction Crohn’s disease and ulcerative colitis are the main clinical phenotypes of inflammatory bowel disease (IBD). Both forms of IBD can increase the incidence of gastrointestinal and colon cancers, and both ones are associated with significant
A. S. Zherebiatiev, A. M. Kamyshnyi
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Neuroendocrine tumor of the small intestine

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019
Intestinal carcinoid is a type of neuroendocrine neoplasia of the small intestine that rarely presents with clinical manifestations. In some cases, it has an aggressive and highly symptomatic behavior, so the clinical suspicion must be high to make an ...
Javier Martínez-Navarro, Adaris Callender-Hernández, Lisanka Fumero-Roldán   +2 more
doaj  

Characteristics of the Gut Microbiota in Different Segments of the Gastrointestinal Tract of Big-Eyed Bamboo Snake (Pseudoxenodon macrops)

Animals
Snakes are model animals to study energy balance, but studies on the gut microbiota of the animals are rather scarce. To fill the gap, we used metagenome sequencing to investigate the microbial community composition and adaptability in the stomach, small
Ruijia Xiang, Ji Chen, Ji Wang, Huina Song, Jiuyan Jiang, Fei Wu, Jingxue Luo, Mingwen Duan, Guangxiang Zhu   +8 more
doaj   +1 more source

Purification and characterization of deoxyribonuclease from small intestine of camel Camelus dromedarius

Journal of Genetic Engineering and Biotechnology, 2017
The chromatography of deoxyribonuclease (DNase) from small intestine of camel Camelus dromedarius by DEAE-Sepharose separated three isoforms DNase 1, DNase 2 and DNase 3. The DNase 3 was purified to homogeneity by chromatography on Sephacryl S-200.
Somia S. Abdel-Gany, Mohamed O. El-Badry, Afaf S. Fahmy, Saleh A. Mohamed   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Clinico-pathological spectrum of small intestinal lesions at a tertiary care hospital [PDF]

Al Ameen Journal of Medical Sciences, 2020
Background: Small intestine is affected by various diseases ranging from developmental abnormalities, inflammatory diseases, malignancies etc. This study was carried out to study the occurrence and evaluate histopathology of small intestinal lesions and ...
M.H. Prabhu Mural, N.V. Kalyan, Mallikarjun A. Pattanashetti, Shivakumar S. Inamdar   +3 more
doaj