Results 61 to 70 of about 429,180 (269)

SARCOMA OF THE SMALL, INTESTINE [PDF]

The American Journal of the Medical Sciences, 1900
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openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

TO THE QUESTION OF DIAGNOSTICS AND PATHOGENETIC THERAPY OF ENTEROPATHY IN PATIENTS WITH CHOLELITHIASIS

Архивъ внутренней медицины, 2016
The aim. Specification the features of violations of the functional characteristics of the small intestine and definition the way of correction in patients with cholelithiasis. Materials and methods. 75 patients with prestone stage of cholelithiasis were
Ya. M. Vakhrushev, A. P. Lukashevich
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

Journal of Pharmacological Sciences, 2017
Peroxisome proliferator-activated receptor α (PPARα) is a well-known therapeutic target for treating hyperlipidemia. K-877 is a novel selective PPARα modulator (SPPARMα) that enhances PPARα transcriptional activity with high selectivity and potency ...
Kenta Takei, Yoshimi Nakagawa, Yunong Wang, Song-iee Han, Aoi Satoh, Motohiro Sekiya, Takashi Matsuzaka, Hitoshi Shimano   +7 more
doaj   +1 more source

Small Intestinal Diverticulitis [PDF]

Clinical Gastroenterology and Hepatology, 2010
van Weyenberg, S.J.B., Mulder, C.J.J., van Waesberghe, J.H.T.M.   +2 more
openaire   +4 more sources

Volvulus of the Small Intestine

Annals of Surgery, 1988
At the Mayo Clinic, six patients with primary volvulus and 51 with secondary volvulus were treated during a 10-year period. Volvulus of the small intestine must be considered when a patient presents with small-bowel obstruction, and early operative intervention should be undertaken to prevent vascular compromise.
R C, Frazee, P, Mucha, M B, Farnell, J A, van Heerden   +3 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The influence of intestine-based treatment using Xuan Bai Cheng Qi Tang on the concentration of trace elements in the main organs of COPD rats

Journal of Traditional Chinese Medical Sciences, 2017
Objective: To test two theories from traditional Chinese medicine: “exterior–interior relationship between the lung and large intestine” and “treating from the intestine principle for lung disorders”. The influence of intestine-based treatment using Xuan
Jiamin Yang, Yan Sun, Jinghong Hu, Xianggen Zhong, Fengjie Zheng, Min Wang, Yanan Wei, Jinchao Zhang, Yuhang Li   +8 more
doaj   +1 more source