Results 91 to 100 of about 194,563 (311)

Inverse relationship between genetic diversity and epigenetic complexity [PDF]

, 2008
Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Beluga, Delphinapterus leucas, Distribution and Survey Effort in the Gulf of Alaska [PDF]

, 2000
Beluga, Delphinapterus leucas, distribution in the Gulf of Alaska and adjacent inside waters was examined through a review of surveys conducted as far back as 1936.
Laidre, Kristin L., Mahoney, Barbara A., Rugh, David J., Shelden, Kim E. W.   +3 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Large‐scale patterns of seed removal by small mammals differ between areas of low‐ versus high‐wolf occupancy

Ecology and Evolution, 2020
Because most tree species recruit from seeds, seed predation by small‐mammal granivores may be important for determining plant distribution and regeneration in forests.
Jennifer L. Chandler, Timothy R. Van Deelen, Nathan P. Nibbelink, John L. Orrock   +3 more
doaj   +1 more source

Wikipedia as an encyclopaedia of life [PDF]

, 2010
In his 2003 essay E O Wilson outlined his vision for an “encyclopaedia of life” comprising “an electronic page for each species of organism on Earth”, each page containing “the scientific name of the species, a ...
C Bizer, C Rinaldo, C Thomas, D Hull, E Garfield, E Pennisi, E Wilson, F Krell, G Nelson, J Giles, JR Gregg, JW Huss, JW Huss, LB Holthuis, M Pickford, M Waldrop, MI Bidartondo, PD Bridge, RC Buck, RD Page, RDM Page, Roderic D. M. Page, S Lawrence, T Lehmann, T Lehmann, WE Schevill, WE Schevill, YL Werner   +27 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Human–Wildlife Interaction—A Social Survey

Animals
With the results of a survey presented in this paper, we provide insight into public attitudes towards dealing with wildlife. Based on 1569 data sets derived from participating stakeholders, we inquired about the individual experience the participants ...
Lara-Luisa Grundei, Franziska M. Schöttes, Friederike Gethöffer, Daniel Tost, Laurin Kluge, Ursula Siebert, Michael Pees   +6 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

MIDDLE PLEISTOCENE SMALL MAMMAL FAUNAS OF EASTERN AND WESTERN EUROPE: CHRONOLOGY, CORRELATION

Geography, Environment, Sustainability, 2012
Many new very important Middle Pleistocene small mammal localities of Europe were discovered during the last decades. These new data permit to divide the Middle Pleistocene geological sequences of Eastern and Western Europe and carried out the ...
Anastasia Markova, Thijs van Kolfschoten
doaj   +1 more source