Results 181 to 190 of about 357,739 (266)

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Paramyxo- and coronavirus diversity and host associations in non-volant small mammals: evidence of viral sharing. [PDF]

Virus Evol
Mortlock M, Geldenhuys M, Keith M, Rademan R, Swanepoel LH, Von Maltitz EF, Kearney T, Markotter W.   +7 more
europepmc   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Ecological determinants driving orthohantavirus prevalence in small mammals of Europe: a systematic review. [PDF]

One Health Outlook
Fabbri D, Mirolo M, Tagliapietra V, Ludlow M, Osterhaus A, Beraldo P.   +5 more
europepmc   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

The First Study of <i>Borrelia burgdorferi</i> Sensu Lato Persistence in Small Mammals Captured in the <i>Ixodes persulcatus</i> Distribution Area in Western Siberia. [PDF]

Pathogens
Rar V, Yakimenko V, Igolkina Y, Sabitova Y, Fedorets V, Karimov A, Rubtsov G, Epikhina T, Tikunova N.   +8 more
europepmc   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Serological Evidence of Lassa Virus Exposure in Non-<i>Mastomys</i> Small Mammals Within a Hyperendemic Region of North-Central Nigeria: A Pilot Study. [PDF]

Viruses
Edegbene AO, Omotehinwa TO, Anejo-Okopi J, Yaagoubi SE, Shittu OS, Audu O, Abah EO, Ijoganu S, Kwaghgande G, Aju-Ameh C, Abimbola A, Otache E, Ameh E, Danyi J, Ikwu O, Cegbeyi EAM, Agboola OO, Okoeguale J, Eifediyi RA, Agbo EB, Idoko JA, Ujah IOA, Abah SO.   +22 more
europepmc   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Small mammals in a biodiversity hotspot harbor viruses of emergence risk. [PDF]

Natl Sci Rev
Feng Y, Kuang G, Pan Y, Wang J, Yang W, Wu WC, Pan H, Wang J, Han X, Yang L, Xin GY, Shan YT, Gou QY, Liu X, Guo D, Liang G, Holmes EC, Gao Z, Shi M.   +18 more
europepmc   +1 more source