Results 191 to 200 of about 390,519 (313)

Virome Analysis of Small Mammals from the Brazilian Amazon. [PDF]

Viruses
Hernández LHA, da Silva FS, da Paz TYB, Dias DD, de Barros BCV, Nunes BTD, Casseb LMN, da Silva SP, da Costa Vasconcelos PF, Cruz ACR.   +9 more
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Infectome analysis of small mammals in Southern China reveals pathogen ecology and emerging risks. [PDF]

Nat Commun
Xin G, Wang D, Zhang X, Cen Q, Peng M, Liao Y, Wang J, Le S, Cheng J, Wu WC, Hou X, Luo G, Gou Q, Kong J, Pan Z, Li D, Gan S, Chen A, Zhao H, Shi P, Ren Z, Zhao W, Liu J, Jia P, Sun C, Lin W, Wu J, Kuang G, Chen J, Li J, Holmes EC, Deng Z, Shi M.   +32 more
europepmc   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Bartonella infection in small mammals and their ectoparasites from the Central Highlands of Madagascar: diversity and implication in future zoonotic surveillance. [PDF]

Parasit Vectors
Maminirina LA, Parany MNJ, Rasoamalala F, Andrianiaina A, Randriamiharisoa LO, Rasoanoro M, Rahajandraibe S, Soarimalala V, Randrianarivelojosia M, Ratahiriarisoa D, Rajerison M, Goodman SM, Ramasindrazana B.   +12 more
europepmc   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Impact of habitat modifications on flea (Siphonaptera) infestation dynamics of non-volant small mammals across wildlife-human interfaces in Tanzania. [PDF]

Int J Parasitol Parasites Wildl
Msoffe VT, Mwombeki FK, Thomas CA, Lyimo CM, Katakweba AS, Misinzo G, Mnyone LL.   +6 more
europepmc   +1 more source

In Vivo Microplastic Detection With Photoacoustic Imaging

Advanced Science, EarlyView.
ABSTRACT Microplastics are posing an escalating threat to both ecological systems and human health. Yet, current methods for investigating their bioaccumulation are highly invasive, requiring destructive analysis of ex vivo tissues via mass spectrometry, dye labelling, or Raman microspectroscopy.
Joseph C. Bear, Olumide Ogunlade, Jayvian Mavi, Emily J. Deniszczyc, Daolong Chen, Heeva Javaheri, Paul Beard, Mark F. Lythgoe, Daniel J. Stuckey, P. Stephen Patrick   +9 more
wiley   +1 more source

Virome characterization of wild small mammals provides new insight into zoonotic pathogens in West Africa. [PDF]

Microbiome
Zhang XA, Zhang MQ, Liu YW, Lin L, Zhang JT, George T, Jalloh MB, Sevalie S, Kargbo KB, Jiang BG, Mi ZQ, Wang SC, Si GQ, Zhang L, Fang LQ, Chen WW, Dong G, Huang WJ, Liu W.   +18 more
europepmc   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source