Results 231 to 240 of about 5,727,217 (300)

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi From Patients and Small Mammals in Xiangyun County, Yunnan Province, China. [PDF]

Vet Med Sci
Chen L, Kong YC, Tian JW, Han PY, Wu S, He CJ, Ren TL, Wang B, Qin L, Zhang YZ.   +9 more
europepmc   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Small mammals in a biodiversity hotspot harbor viruses of emergence risk. [PDF]

Natl Sci Rev
Feng Y, Kuang G, Pan Y, Wang J, Yang W, Wu WC, Pan H, Wang J, Han X, Yang L, Xin GY, Shan YT, Gou QY, Liu X, Guo D, Liang G, Holmes EC, Gao Z, Shi M.   +18 more
europepmc   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Paramyxo- and coronavirus diversity and host associations in non-volant small mammals: evidence of viral sharing. [PDF]

Virus Evol
Mortlock M, Geldenhuys M, Keith M, Rademan R, Swanepoel LH, Von Maltitz EF, Kearney T, Markotter W.   +7 more
europepmc   +1 more source

Ecological determinants driving orthohantavirus prevalence in small mammals of Europe: a systematic review. [PDF]

One Health Outlook
Fabbri D, Mirolo M, Tagliapietra V, Ludlow M, Osterhaus A, Beraldo P.   +5 more
europepmc   +1 more source

Infestation, community structure, seasonal fluctuation and climate-driven dynamics of mites on small mammals at a focus of scrub typhus in southwest China. [PDF]

Front Vet Sci
Yin PW, Lv Y, Guo XG, Song WY, Fan R, Zhao CF, Zhang ZW, Zhao YF, Dong WG, Jin DC.   +9 more
europepmc   +1 more source

Assessing the diversity of zoonotic bacterial agents in rodents and small mammals in Iran. [PDF]

Eur J Public Health
Rezaie N, Latifian M, Ghasemi A, Mahmoudi A, Baseri N, Omidi AH, Esmaeili P, Esmaeili S, Mostafavi E.   +8 more
europepmc   +1 more source

Serological Evidence of Lassa Virus Exposure in Non-<i>Mastomys</i> Small Mammals Within a Hyperendemic Region of North-Central Nigeria: A Pilot Study. [PDF]

Viruses
Edegbene AO, Omotehinwa TO, Anejo-Okopi J, Yaagoubi SE, Shittu OS, Audu O, Abah EO, Ijoganu S, Kwaghgande G, Aju-Ameh C, Abimbola A, Otache E, Ameh E, Danyi J, Ikwu O, Cegbeyi EAM, Agboola OO, Okoeguale J, Eifediyi RA, Agbo EB, Idoko JA, Ujah IOA, Abah SO.   +22 more
europepmc   +1 more source