Results 241 to 250 of about 390,519 (313)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Infestation, community structure, seasonal fluctuation and climate-driven dynamics of mites on small mammals at a focus of scrub typhus in southwest China. [PDF]

Front Vet Sci
Yin PW, Lv Y, Guo XG, Song WY, Fan R, Zhao CF, Zhang ZW, Zhao YF, Dong WG, Jin DC.   +9 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Paramyxo- and coronavirus diversity and host associations in non-volant small mammals: evidence of viral sharing. [PDF]

Virus Evol
Mortlock M, Geldenhuys M, Keith M, Rademan R, Swanepoel LH, Von Maltitz EF, Kearney T, Markotter W.   +7 more
europepmc   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Ecological determinants driving orthohantavirus prevalence in small mammals of Europe: a systematic review. [PDF]

One Health Outlook
Fabbri D, Mirolo M, Tagliapietra V, Ludlow M, Osterhaus A, Beraldo P.   +5 more
europepmc   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Small mammals in a biodiversity hotspot harbor viruses of emergence risk. [PDF]

Natl Sci Rev
Feng Y, Kuang G, Pan Y, Wang J, Yang W, Wu WC, Pan H, Wang J, Han X, Yang L, Xin GY, Shan YT, Gou QY, Liu X, Guo D, Liang G, Holmes EC, Gao Z, Shi M.   +18 more
europepmc   +1 more source

Assessing the diversity of zoonotic bacterial agents in rodents and small mammals in Iran. [PDF]

Eur J Public Health
Rezaie N, Latifian M, Ghasemi A, Mahmoudi A, Baseri N, Omidi AH, Esmaeili P, Esmaeili S, Mostafavi E.   +8 more
europepmc   +1 more source

The First Study of <i>Borrelia burgdorferi</i> Sensu Lato Persistence in Small Mammals Captured in the <i>Ixodes persulcatus</i> Distribution Area in Western Siberia. [PDF]

Pathogens
Rar V, Yakimenko V, Igolkina Y, Sabitova Y, Fedorets V, Karimov A, Rubtsov G, Epikhina T, Tikunova N.   +8 more
europepmc   +1 more source