Results 61 to 70 of about 357,739 (266)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Influence of some environmental parameters on small mammals (Rodentia, Insectivora) in the Central Alps

open access: yesHystrix, the Italian Journal of Mammalogy, 1997
<strong>Abstract</strong> This paper points out the relationships occurring between small mammal populations studied in some areas of the central-Western italian Alpine Arch, and some environmental parameters that characterize the Alpine ...
Barbara Chiarenzi   +2 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

A Newcastle disease outbreak in backyard and free-range poultry in Slovenia

open access: yesFrontiers in Veterinary Science
Newcastle disease (ND) is a highly contagious and economically important viral disease of poultry, caused by virulent strains of Orthoavulavirus javaense (OAVJ).
Zoran Žlabravec   +10 more
doaj   +1 more source

New record of the Oriental house rat, Rattus tanezumi, in Nepal inferred from mitochondrial Cytochrome B gene sequences

open access: yesMitochondrial DNA. Part B. Resources, 2018
This study determines the presence of R. tanezumi from in Nepal using morphological and molecular analyses. Morphologically, it is indistinguishable with R. rattus owing to similar fur colour and morphometric data.
Pradeep Adhikari   +8 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

A case study of critical points for the entry and spread of Salmonella Infantis in a broiler farm

open access: yesIrish Veterinary Journal
Salmonella Infantis is a zoonotic pathogen that frequently persists in broiler production systems, posing a risk to food safety and animal health. Understanding its entry and spread in these systems can inform control measures and reduce contamination. A
Bojan Papić   +5 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Himalayan Vultures in Khodpe, far-west Nepal: is there any threat?

open access: yesJournal of Threatened Taxa, 2015
There is evidence that Himalayan Vulture Gyps himalayensis is susceptible to the veterinary drug diclofenac, which is responsible for the decline of other Gyps species across South Asia.
Manoj Kumar Joshi   +3 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

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