Results 81 to 90 of about 5,727,217 (300)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

The grey zone of taxonomy—The case of the Sikkim Myotis (Chiroptera: Vespertilionidae: Myotis sicarius), first recorded from Southeast Asia [PDF]

open access: yesVertebrate Zoology
In taxonomic works, the weight to be given to morphological, mitochondrial, or nuclear signals, and the assessment of differences as species or subspecies distinctions has also varied considerably over the past decades and is largely a subjective ...
Dorottya Győrössy   +6 more
doaj   +3 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Serum Lipid Reference Intervals of High-Density, Low-Density and Non-High-Density Lipoprotein Cholesterols and Their Association with Atherosclerosis and Other Factors in Psittaciformes

open access: yesAnimals
Atherosclerosis is highly prevalent among captive psittacine populations and is a frequent cause of veterinary consultations. Ante-mortem diagnosis remains challenging, but the serum lipoprotein analysis has been suggested as a useful tool for ...
Matthias Janeczek   +5 more
doaj   +1 more source

Utilisation of seed resources by small mammals : a two-way interaction [PDF]

open access: yes, 2009
Within the Australian wet tropics bioregion, only 900 000 hectares of once continuous rainforest habitat between Townsville and Cooktown now remains. While on the Atherton Tableland, only 4% of the rainforest that once occurred there remains today with ...
Elmouttie, David
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

New record of the Oriental house rat, Rattus tanezumi, in Nepal inferred from mitochondrial Cytochrome B gene sequences

open access: yesMitochondrial DNA. Part B. Resources, 2018
This study determines the presence of R. tanezumi from in Nepal using morphological and molecular analyses. Morphologically, it is indistinguishable with R. rattus owing to similar fur colour and morphometric data.
Pradeep Adhikari   +8 more
doaj   +1 more source

Foraging behaviour of small mammals for sessile prey [PDF]

open access: yes, 1995
Not ...
Krause, Elke Alexandra Klever
core  

Arsenic in small, mammals

open access: yes, 1992
Acute arsenic poisoning had been reported since the nineteenth century from smelting and refining activities. Many of these studies show that arsenic accumulated in the animals is not to concentration greater than 1 ug.g-1. This study shows low levels of
Roberts, R.D., Ismail, A.
core   +1 more source

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