Results 91 to 100 of about 645,880 (357)

Strategies for High-Throughput, Templated Zeolite Synthesis

, 2002
How best to design and redesign high-throughput experiments for zeolite synthesis is addressed. A model that relates materials function to chemical composition of the zeolite and the structure directing agent is introduced.
Chen, Ligang, Deem, Michael W.
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Novel allosteric sites on Ras for lead generation. [PDF]

PLoS ONE, 2011
Aberrant Ras activity is a hallmark of diverse cancers and developmental diseases. Unfortunately, conventional efforts to develop effective small molecule Ras inhibitors have met with limited success.
Barry J Grant, Suryani Lukman, Harrison J Hocker, Jaqueline Sayyah, Joan Heller Brown, J Andrew McCammon, Alemayehu A Gorfe   +6 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Aptamers as Reagents for High-Throughput Screening

BioTechniques, 2001
The identification of new drug candidates from chemical libraries is a major component of discovery research in many pharmaceutical companies. Given the large size of many conventional and combinatorial libraries and the rapid increase in the number of ...
Louis S. Green, Carol Bell, Nebojsa Janjic   +2 more
doaj   +1 more source

Canvass: a crowd-sourced, natural-product screening library for exploring biological space [PDF]

, 2018
NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A.
Andrade, Rodrigo B., Bougie, Danielle, Boxer, Matthew B., Brimacombe, Kyle R., Brown, Lauren E., Brown, M Kevin, Burns, Noah Z., Cha, Jin K., Cheff, Dorian M., Cheng, Ken, Clardy, Jon, Clement, Jason A., Coussens, Nathan P., Crooks, Peter A., Cuny, Gregory D., Dillon, Christopher, Dorjsuren, Dorjbal, Eastman, Richard T., Ganor, Jake, Garg, Neil K., Goess, Brian C., Grossman, Robert B., Guha, Rajarshi, Hall, Matthew D., Henderson, Mark J., Huang, Ruili, Hughes, Chambers C., Iannotti, Michael J., Inglese, James, Itkin, Zina, Jadhav, Ajit, Johnston, Jeffrey N., Joullie, Madeleine M., Karavadhi, Surendra, Kearney, Sara E., Kinghorn, A. Douglas, Kingston, David G. I., Klumpp-Thomas, Carleen, Krische, Michael J., Kwon, Ohyun, Lee, Tobie D., Lynch, Caitlin, Maimone, Thomas J., Majumdar, Susruta, Maloney, Katherine N., Mevers, Emily E., Michael, Sam, Mohamed, Enas, Moreno, Jesus, Morrill, Lucas A., Murphy, Brian T., Nagorny, Pavel, Olson, David E., Overman, Larry E., Picazo, Elias, Porco, John A., Ren, Tianjing, Rivas, Fatima, Rohde, Jason M., Ross, Samir A., Roth, Jacob S., Sakamuru, Srilatha, Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T., Shen, Ben, Shen, Min, Shi, Wei, Shinn, Paul, Simeonov, Anton, Snyder, John K., Stephenson, Corey R. J., Sun, Wei, Susick, Robert B., Tan, Derek S., Tang, Yi, Taylor, Richard E., Thomson, Regan J., Titus, Steven A., Verano, Alyssa L., Vosburg, David A., Wan, Kanny K., Wu, Jimmy, Wuest, William M., Xia, Menghang, Xu, Zhengren, Yasgar, Adam, Zahoranszky-Kohalmi, Gergely, Zakarian, Armen, Zhang, Ya-Qin, Zhang, Yufeng, Zhao, Jinghua, Zhao, Tongan, Zheng, Wei, Zuo, Zhong   +94 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Do Molecular Fingerprints Identify Diverse Active Drugs in Large-Scale Virtual Screening? (No)

Pharmaceuticals
Computational approaches for small-molecule drug discovery now regularly scale to the consideration of libraries containing billions of candidate small molecules.
Vishwesh Venkatraman, Jeremiah Gaiser, Daphne Demekas, Amitava Roy, Rui Xiong, Travis J. Wheeler   +5 more
doaj   +1 more source

Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]

, 2014
Peer reviewedPublisher ...
Barelle, Caroline, Empting, Martin, Grzeschik, Julius, Kolmar, Harald, Könning, Doreen, Zielonka, Stefan   +5 more
core   +1 more source

A virtual library of small molecules mimicking dipeptides

Archiv der Pharmazie
AbstractVirtual combinatorial libraries are prevalent in drug discovery due to improvements in the prediction of synthetic reactions that can be performed. This has gone hand in hand with the development of virtual screening capabilities to effectively screen the large chemical spaces spanned by exhaustive enumeration of reaction products.
Victor Jun Yu Lim, Hans‐Dieter Gerber, Hannes Schihada, Van Tuan Trinh, Daniel Hilger, Olalla Vázquez, Peter Kolb   +6 more
openaire   +2 more sources