Results 121 to 130 of about 194,605 (341)

Single-Molecule Analysis of i-motif Within Self-Assembled DNA Duplexes and Nanocircles [PDF]

, 2019
The cytosine (C)-rich sequences that can fold into tetraplex structures known as i-motif are prevalent in genomic DNA. Recent studies of i-motif–forming sequences have shown increasing evidence of their roles in gene regulation.
Cox, Bobby D., Dhakal, Soma, Kaur, Anisa, Megalathan, Anoja, Reiner, Joseph E., Sapkota, Kumar, Wilkerson, Peter D.   +6 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Natural product-likeness score revisited: an open-source, open-data implementation

BMC Bioinformatics, 2012
Background Natural product-likeness of a molecule, i.e. similarity of this molecule to the structure space covered by natural products, is a useful criterion in screening compound libraries and in designing new lead compounds.
Jayaseelan Kalai Vanii, Moreno Pablo, Truszkowski Andreas, Ertl Peter, Steinbeck Christoph   +4 more
doaj   +1 more source

Detection of small-molecule enzyme inhibitors with peptides isolated from phage-displayed combinatorial peptide libraries [PDF]

, 2000
Robin Hyde‐DeRuyscher, LA Paige, DJ Christensen, N Hyde-DeRuyscher, Alison Lim, ZL Fredericks, Janice E. Kranz, Paul Gallant, J Zhang, SM Rocklage, DM Fowlkes, PA Wendler, Paul T. Hamilton   +12 more
openalex   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.

PLoS ONE, 2019
CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types.
Thomas W Miller, Joshua D Amason, Elsa D Garcin, Laurence Lamy, Patricia K Dranchak, Ryan Macarthur, John Braisted, Jeffrey S Rubin, Teresa L Burgess, Catherine L Farrell, David D Roberts, James Inglese   +11 more
doaj   +1 more source

Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells

Disease Models & Mechanisms, 2011
SUMMARY Combination therapy, in which two or more agents are applied, is more effective than single therapies for combating cancer. For this reason, combinations of chemotherapy with radiation are being explored in clinical trials, albeit with an ...
Anthony Edwards, Mara Gladstone, Petros Yoon, David Raben, Barbara Frederick, Tin Tin Su   +5 more
doaj   +1 more source

Altered sequence specificity identified from a library of DNA-binding small molecules [PDF]

, 2000
Vladimir Guelev, Matthew T. Harting, R. Scott Lokey, Brent L. Iverson   +3 more
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.

PLoS Medicine, 2007
BackgroundThe presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit.
Kimberly Stegmaier, Jenny S Wong, Kenneth N Ross, Kwan T Chow, David Peck, Renee D Wright, Stephen L Lessnick, Andrew L Kung, Todd R Golub   +8 more
doaj   +1 more source