Results 131 to 140 of about 645,880 (357)

Unbiased high-throughput screening of drug-repurposing libraries identifies small-molecule inhibitors of clot retraction

Blood Advances
: Platelet clot retraction, the ultimate phase of platelet thrombus formation, is critical for clot stabilization. It requires functional αIIbβ3 receptors, fibrin, and the integrated actions of the actin-myosin contractile and cytoskeletal systems ...
Lorena Buitrago, Miriam-Rose Menezes, Chloe Larson, Jihong Li, Thomas Kartika, Priyam Banerjee, Fraser Glickman, Barry Coller   +7 more
doaj   +1 more source

Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors [PDF]

, 2013
Please cite as follows: Chakravorty, S. et al. 2014. Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors.
Chakravorty, Santanu, Fang, Zhizhou, Hodson, Luke E., Klein, Hanna F., Pelly, Stephen C., Rabillier, Matthias, Rauh, Daniel, Richters, Andre, Van Otterlo, Willem A. L.   +8 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

NP-Scout: Machine Learning Approach for the Quantification and Visualization of the Natural Product-Likeness of Small Molecules

Biomolecules, 2019
Natural products (NPs) remain the most prolific resource for the development of small-molecule drugs. Here we report a new machine learning approach that allows the identification of natural products with high accuracy.
Ya Chen, Conrad Stork, Steffen Hirte, Johannes Kirchmair   +3 more
doaj   +1 more source

Identification and Biological Evaluation of a Novel and Potent Small Molecule Radiation Sensitizer via an Unbiased Screen of a Chemical Library [PDF]

, 2007
Brian E. Lally, Geoffrey A. Geiger, Steven J. Kridel, Alice E. Arcury‐Quandt, Michael E. Robbins, Nancy D. Kock, Kenneth T. Wheeler, Prakash Peddi, Alexandros G. Georgakilas, Gary D. Kao, Constantinos Koumenis   +10 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Optimization and development of a high-throughput TR-FRET screening assay for SLIT2/ROBO1 interaction

SLAS Discovery
The SLIT2/ROBO1 signaling axis plays a critical role in cell migration, angiogenesis, and immune regulation, contributing to tumor progression, metastasis, and therapy resistance.
Somaya A. Abdel-Rahman, Moustafa T. Gabr
doaj   +1 more source

2013 REU Poster: Small Molecule Evolution: A Biomimetic Approach to Small Molecule Lead Generation and Optimization [PDF]

, 2013
Poster presentation at REU Summer's End Research Symposium, 2013, by REU participant Tiara Bloodworth, MassBay Community College - Aaron Beeler group, Dr.
Bloodworth, Tiara L.
core   +1 more source

Small-Molecule Library Subset Screening as an Aid for Accelerating Lead Identification [PDF]

, 2014
Maureen H. Beresini, Yichin Liu, Timothy D. Dawes, Kevin Clark, Linda Orren, Stephen Schmidt, Rebecca Turincio, Steven W. Jones, Richard A. Rodriguez, Peter Thana, Daniel Hascall, Daniel P. Gross, Nicholas J. Skelton   +12 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source