Results 141 to 150 of about 194,605 (341)

Synthesis and screening of a cyclic peptide library: Discovery of small-molecule ligands against human prolactin receptor [PDF]

, 2008
Tao Liu, Sang Hoon Joo, Jeffrey L. Voorhees, Charles L. Brooks, Dehua Pei   +4 more
openalex   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Discovery and Development of a Small Molecule Library with Lumazine Synthase Inhibitory Activity [PDF]

, 2009
Arindam Talukdar, Meghan E. Breen, Adelbert Bacher, Boris Illarionov, Markus Fischer, Gunda I. Georg, Qi-Zhuang Ye, Mark Cushman   +7 more
openalex   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters

Nature Communications
Disruption of alternative splicing frequently causes or contributes to human diseases and disorders. Consequently, there is a need for efficient and sensitive reporter assays capable of screening chemical libraries for compounds with efficacy in ...
Andrew J. Best, Ulrich Braunschweig, Mingkun Wu, Shaghayegh Farhangmehr, Adrian Pasculescu, Justin J. Lim, Lim Caden Comsa, Mark Jen, Jenny Wang, Alessandro Datti, Jeffrey L. Wrana, Sabine P. Cordes, Rima Al-awar, Hong Han, Benjamin J. Blencowe   +14 more
doaj   +1 more source

Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries [PDF]

, 2009
Matthew Clark, Raksha Acharya, Christopher C. Arico-Muendel, Svetlana Belyanskaya, Dennis R. Benjamin, Neil R Carlson, Paolo A. Centrella, Cynthia H. Chiu, Steffen P. Creaser, John W. Cuozzo, Christopher P. Davie, Yun Ding, G. Joseph Franklin, Kurt D Franzen, Malcolm L. Gefter, Steven P Hale, Nils Jakob Vest Hansen, David I. Israel, Jinwei Jiang, Malcolm J. Kavarana, Michael S. P. Kelley, Christopher S. Kollmann, Fan Li, Kenneth Lind, Sibongile Mataruse, Patrícia Flores de Medeiros, Jeffrey A. Messer, Paul J. Myers, Heather P. O’Keefe, Matthew C. Oliff, Cecil Rise, Alexander L. Satz, Steven R. Skinner, Jennifer L. Svendsen, Lujia Tang, Kurt van Vloten, Richard W. Wagner, Gang Yao, Baoguang Zhao, Barry A. Morgan   +39 more
openalex   +1 more source

The octet rule in chemical space: Generating virtual molecules

, 2017
We present a generator of virtual molecules that selects valid chemistry on the basis of the octet rule. Also, we introduce a mesomer group key that allows a fast detection of duplicates in the generated structures. Compared to existing approaches, our
Hamaekers, Jan, Israels, Rafel, Maaß, Astrid   +2 more
core   +1 more source

High Fidelity Small Molecule Dna-Encoded Yoctoreactor Libraries

Basel Life Science Week, 2015
Yoctoreactor technology (yR) is employed to generate DNA-encoded small molecule libraries of maximum fidelity for seamless drug discovery. Through efficient self-assembly of DNA oligonucleotides, 3D DNA structures are formed ? each is serving as a small chemical reactor.
openaire   +3 more sources

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source