Results 171 to 180 of about 109,018 (245)

Artificial Intelligence in Selected Domains of Drug Discovery: A Critical Narrative Review. [PDF]

Drug Des Devel Ther
Bin Abdulqader MI, Alsaqabi AA, Mohammed AE, Alghamdi SS.   +3 more
europepmc   +1 more source

Evolution‐Driven Bio‐Composite Aerogels for Self‐Adaptive Thermal Regulation and Energy Storage

Advanced Materials, EarlyView.
Inspired by nature's multiphase integration, a single chitosan (CTS)–metal chloride (MCl3) coordination precursor is engineered to enable sequential material and functional evolution. The resulting metal ion‐coordinated chitosan (CTS–M) aerogels exhibit humidity‐adaptive thermal insulation for battery safety, while carbonization yields conductive ...
Xiaoxue Zhang, Xiaodong Wang, Jianping Zeng, Zhihua Zhang, Shanyu Zhao, Jun Shen   +5 more
wiley   +1 more source

DrugForm-TAS: Target-Agnostic Selectivity as Proteome-wide Binding Propensity Estimation. [PDF]

Comput Struct Biotechnol J
Tashchilova A, Khokhlov I, Seikin A, Bugaev-Makarovskiy N, Glushkova O, Yudin V, Keskinov A, Yudin S, Svetlichnyy D, Skvortsova V.   +9 more
europepmc   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

Structural determination of natural products at speeds and scale of high-throughput screening.

Nat Prod Rep
Thornburg CC, Kumar R, Wang D, O'Keefe BR, Grkovic T.   +4 more
europepmc   +1 more source

Optoelectronic Nanofluidic Neural Networks for Ionic Computing

Advanced Materials, EarlyView.
An ion‐based optoelectronic nanofluidic memristor enables neuromorphic computing in aqueous environments. With tunable ionic memory and multimodal synaptic plasticity, it realizes densely connected ionic neural networks capable of image classification, motion prediction, logic computation, and real‐time in‐sensor computing, advancing fully connected ...
Yaxin Huang, Zhiyuan Du, Changjin Wu, Binglin Zeng, Yingnan Cao, Mingliang Li, Liren Zhang, Qingxin Guo, Chao Huang, Can Li, Jinyao Tang   +10 more
wiley   +1 more source

Optimization of the Quantum-Si Platinum Single-Molecule Protein Sequencing Platform Toward Improved Complex-Matrix Protein Identification. [PDF]

ACS Omega
Leski TA, Brown SM, Johnson ZT, Dean SN, Goldman ER, Stenger DA.   +5 more
europepmc   +1 more source

Can Elastomers Combine Stiffness, Toughness and Fatigue Resistance?

Advanced Materials, EarlyView.
This review studies how the molecular and macroscopic architecture of elastomers influence their mechanical properties including: stiffness, stretchability, toughness, fatigue resistance, and damping behavior. By linking the structure to performance, it proposes design principles for advanced elastomeric systems that combine mechanical properties ...
Eva Baur, Esther Amstad
wiley   +1 more source

Unleashing the power of DNA-encoded libraries for challenging targets in drug discovery. [PDF]

Pharm Sci Adv
Du N, Li Y, Lou Q, Zhang G, Li Y, Li Y.
europepmc   +1 more source

Hybrid Amyloid–Boron Nitride Aerogels for Lightweight Sound Insulation

Advanced Materials, EarlyView.
Amyloid fibrils template the mild formation of boron nitride–rich hybrid aerogels with hierarchical porosity, enhanced BN‐like ordering, and fibril‐reinforced mechanics. These ultralight materials combine thermal stability with strong sound absorption and transmission loss, offering a sustainable bio‐assisted route toward lightweight acoustic shields ...
Mohammad Peydayesh, Andrin Lustgarten, Stefan Schoenwald, Enrico Boschi, My Hanh Bui, Ali Miserez, Felix Donat, Christoph R. Müller, Raffaele Mezzenga   +8 more
wiley   +1 more source