Results 251 to 260 of about 194,605 (341)

T1171 High-Throughput Screening (HTS) of a 290,000-Small Molecule Compound Library for Inhibitors of the Gene Encoding the Pro-Proliferative Human KrüPpel-Like Factor 5 (KLF5)

, 2010
Agnieszka B. Bialkowska, Melissa Crisp, Stephen Schuerer, Becky A. Mercer, Peter Hodder, William Roush, Vincent W. Yang   +6 more
openalex   +1 more source

Toward Zero‐Excess Alkali Metal Batteries: Bridging Experimental and Computational Insights

Advanced Materials, EarlyView.
This review explores zero‐excess alkali metal batteries, highlighting anode–electrolyte interfaces, metal nucleation, dendrite growth, and SEI formation while comparing Li, Na, and K metals. It critically examines electrolyte and separator roles, emphasizing substrate design, electrolyte modifications, interfacial engineering, and solid‐state ...
Pan He, Neubi Francisco Xavier Jr, Matthias Johannes Golomb, Yupei Han, Yuheng Du, Qiong Cai, Yang Xu   +6 more
wiley   +1 more source

Designing Physical Unclonable Functions From Optically Active Materials

Advanced Materials, EarlyView.
Assigning unforgeable “fingerprints” to manufactured goods is a key strategy to fight global counterfeiting. Optical physical unclonable functions (PUFs) are chemically generated random patterns of optically active materials serving as unique authenticators.
Maxime Klausen, Junfang Zhang, Molly M. Stevens   +2 more
wiley   +1 more source

Perspectives on Applications of ¹⁹F-NMR in Fragment-Based Drug Discovery. [PDF]

Molecules
Li Q, Kang C.
europepmc   +1 more source

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery. [PDF]

Nat Commun
Petrov D, Plais L, Schira K, Cai J, Keller M, Lessing A, Bassi G, Cazzamalli S, Neri D, Gloger A, Scheuermann J.   +10 more
europepmc   +1 more source

Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening

Hengrui Liu, Arie Zask, F. Forouhar, Sho Iketani, Alana D. N. Williams, Daniel R. Vaz, Dahlya Habashi, Kwan Sam Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell   +14 more
openalex   +1 more source

Ionic Liquid‐Reinforced Multifunctional Hydrogel for the Treatment of Enterocutaneous Fistula

Advanced Materials, EarlyView.
ECFGel is a multifunctional hydrogel engineered to treat infection‐associated ECFs. ECFGel demonstrates outstanding mechanical and biological properties, facilitating easy application, reliable occlusion, and sterilization, while promoting effective healing of infected fistula tracts.
Jinjoo Kim, Hyeongseop Keum, Hassan Albadawi, Ismail Altinbasak, Furkan Yavuz, Erin H. Graf, Nitin Mishra, Rahmi Oklu   +7 more
wiley   +1 more source

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities. [PDF]

J Chem Inf Model
Gusev F, Gutkin E, Gentile F, Ban F, Koby SB, Li F, Chau I, Ackloo S, Arrowsmith CH, Bolotokova A, Ghiabi P, Gibson E, Halabelian L, Houliston S, Harding RJ, Hutchinson A, Loppnau P, Perveen S, Seitova A, Zeng H, Schapira M, Cherkasov A, Isayev O, Kurnikova MG.   +23 more
europepmc   +1 more source

The Role of Artificial Intelligence in Advancing Biosensor Technology: Past, Present, and Future Perspectives

Advanced Materials, EarlyView.
This review explores the transformative role of AI in biosensor technology and provides a holistic interdisciplinary perspective that covers a broader scope of AI‐enabled biosensor technologies across various sectors including healthcare, environmental monitoring, food safety, and agriculture. It also highlights the important role of novel materials in
Tuğba Akkaş, Mahshid Reshadsedghi, Mustafa Şen, Volkan Kılıç, Nesrin Horzum   +4 more
wiley   +1 more source