Results 261 to 270 of about 194,605 (341)

Rapid traversal of vast chemical space using machine learning-guided docking screens. [PDF]

Nat Comput Sci
Luttens A, Cabeza de Vaca I, Sparring L, Brea J, Martínez AL, Kahlous NA, Radchenko DS, Moroz YS, Loza MI, Norinder U, Carlsson J.   +10 more
europepmc   +1 more source

Evaluation and In Situ Library Expansion of Small Molecule MHC-I Inducers

Joey J. Kelly, Sarah E. Newkirk, Mahendra D. Chordia, Marcos M. Pires   +3 more
openalex   +1 more source

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Creating Coarse-Grained Systems with COBY: Toward Higher Accuracy of Complex Biological Systems. [PDF]

J Chem Inf Model
Andreasen MD, Souza PCT, Schiøtt B, Zuzic L.   +3 more
europepmc   +1 more source

Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders

Tilal Elsaman, Magdi Awadalla Mohamed, Abozer Y. Elderdery, Abdullah Alsrhani, Badr Alzahrani, Heba Bassiony Ghanem, Jeremy Mills, Musaed Rayzah, Nasser A. N. Alzerwi, Afnan Alsultan, Bandar Idrees, Fares Rayzah   +11 more
openalex   +1 more source

Spatially Controlled 3‐D Multiplexed Aptamer Patterning in Hydrogels

Advanced Materials Interfaces, EarlyView.
A hydrogel platform based on norbornene‐functionalized polyvinyl alcohol enables high‐resolution, 3‐D multiplexed patterning of DNA aptamers via two‐photon polymerization. Two distinct aptamers are covalently immobilized with single micron‐scale precision across the x, y, and z dimensions.
Kevin Roost, Annina Stuber, Kongchang Wei, Marine de Lapeyrière, Ke Yang, Valentin Gantenbein, Salvador Pané, Ivan Corbeski, Katharina Maniura‐Weber, Nako Nakatsuka   +9 more
wiley   +1 more source

Epigenetic reader chromodomain as a potential therapeutic target. [PDF]

RSC Chem Biol
Sharma S, Hampton JT, Kutateladze TG, Liu WR.   +3 more
europepmc   +1 more source

P-1346. Identification of aminoglycoside 6′-N-acetyltransferase type Ib small molecule inhibitors using mixture-based combinatorial libraries and structure-activity relationship studies

Jan Sklenicka, Tung Tran, Angel J. Magaña, María Soledad Ramirez, Haley M. Donow, Travis LaVoi, Yasir Mamun, Prem P. Chapagain, Radleigh G. Santos, Clemencia Pinilla, Marc A. Giulianotti, Marcelo E. Tolmasky   +11 more
openalex   +1 more source

A Dynamic Spike Sorter for Multiscale Nanoelectrode Array Recordings

Advanced Materials Interfaces, EarlyView.
This work introduces a dynamic spike sorting pipeline that isolates diverse electrical signals from nanoelectrode arrays. Using biophysical simulations to calibrate signal processing, the approach reveals relationships between action potentials and membrane fluctuations, advancing the understanding of neuronal network excitability.
Shivani Shukla, Callum Walsh, Shashank Bansal, Johannes Leugering, Abhinav Uppal, Vikrant Jaltare, Gert Cauwenberghs, Sreekanth H. Chalasani, Zeinab Jahed   +8 more
wiley   +1 more source