Results 281 to 290 of about 194,605 (341)

Small Molecules Identified by an In Silico Docking Screen Targeting Anaphase-Promoting Complex/Cyclosome Subunit 1 (APC1) Potentiate Paclitaxel-Induced Breast Cancer Cell Death. [PDF]

Molecules
Schuyler SC, Gupta R, Nguyen TTB, Weng CY, Chen HY.   +4 more
europepmc   +1 more source

MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens. [PDF]

Proc Natl Acad Sci U S A
Andersson J, Cowland S, Vestergaard M, Yang Y, Liu S, Fang X, Mukund S, Ghimire-Rijal S, Carter C, Chung G, Jacso T, Sarvary I, Hughes PE, Gouliaev A, Payton M, Belmontes B, Caenepeel S, Franch T, Glad S, Husemoen B, Nielsen SJ.   +20 more
europepmc   +1 more source

Docking-Based Classification of SGLT2 Inhibitors. [PDF]

Molecules
Mazoudji A, Ecker GF.
europepmc   +1 more source

Exploring Macrocyclic Chemical Space: Strategies and Technologies for Drug Discovery. [PDF]

Pharmaceuticals (Basel)
Kim T, Baek E, Kim J.
europepmc   +1 more source

A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding

Hess S, Alonso MC, Brand M, Lauw S, Lindenmann U, Göbel K, Geurink PP, Fritz G, Riedl R, Knobeloch K.   +9 more
europepmc   +1 more source

ChemInform Abstract: Synthesis and Applications of Small Molecule Libraries [PDF]

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jonathan A. Ellman, Lorin A. Thompson
openaire   +3 more sources

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Small-molecule discovery through DNA-encoded libraries

Nature Reviews Drug Discovery, 2023
The development of bioactive small molecules as probes or drug candidates requires discovery platforms that enable access to chemical diversity and can quickly reveal new ligands for a target of interest. Within the past 15 years, DNA-encoded library (DEL) technology has matured into a widely used platform for small-molecule discovery, yielding a wide ...
Alexander A. Peterson, David R. Liu
openaire   +2 more sources